Endoscopic
Endoscopic
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内窥镜
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Hà Nội
中科院分区：
文献类型：
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作者：
Nguyen Thao;Nguyễn Thị;T. Ha;Đỗ Tuấn Đạt;Benh Vien;Phụ Sản;Hà Nội
目的：评价单剂量甲氨蝶呤(MTX)治疗未破裂型异位妊娠的疗效。研究设计与方法：采用横断面描述性研究，对2021年7月至2022年6月在河内产科医院妇科门诊接受单剂甲氨蝶呤治疗的98例未破裂型宫外孕患者进行研究。结果：研究参与者的平均年龄为39.5±4.2岁，其中48%的未分娩患者和61.2%的患者有刮宫或流产史。初始β水平<500mIU/ml、异位肿块直径<20 mm的患者治疗成功率最高。初始βhCG水平和异位肿块体积较小与较高的成功率相关，这一差异在统计学上具有显著意义。32.65%的患者出现不良反应，大多较轻微，不需要治疗。结论：较低的初始βhCG水平和较小的异位包块大小与使用甲氨蝶呤治疗未破裂型异位妊娠的成功率有关。
Objective: To evaluate the effectiveness of medical treatment of unruptured ectopic pregnancy with single dose Methotrexate (MTX). Study Design and Methods : A cross-sectional descriptive study was conducted on 98 patients diagnosed with unruptured ectopic pregnancies treated with a single dose of MTX at the gynecology outpatient clinic of Hanoi Obstetrics Hospital from July 2021 to June 2022. Results: The average age of the study participants was 39.5 ± 4.2, with 48% nulliparous patients and 61.2% having a history of curettage or miscarriage. The highest treatment success rate was observed in patients with initial βhCG levels below 500mIU/ml and ectopic mass size smaller than 20mm. Initial βhCG levels and smaller ectopic mass size were associated with higher success rates, and this difference was statistically significant with p < 0.05. Adverse effects were observed in 32.65% of patients, mostly mild and not requiring treatment. Conclusion: Lower initial βhCG levels and smaller ectopic mass size are associated with higher success rates in the treatment of unruptured ectopic pregnancies with MTX