Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography.
Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography.
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DOI：
10.1176/ajp.142.5.564
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发表时间：
1985-05
期刊：
影响因子：
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通讯作者：
A. Wolkin;J. Jaeger;J. Brodie;A. Wolf;J. Fowler;J. Rotrosen;F. Gómez-Mont;R. Cancro
中科院分区：
文献类型：
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作者：
A. Wolkin;J. Jaeger;J. Brodie;A. Wolf;J. Fowler;J. Rotrosen;F. Gómez-Mont;R. Cancro
局部脑代谢率测定正电子发射断层扫描和脱氧葡萄糖法在一组10名慢性精神分裂症患者的躯体治疗前后和8名正常人。在治疗前，精神分裂症患者的额叶和颞叶区域的绝对代谢活性明显低于正常对照组，基底神经节区域的代谢活性有相对亢进的趋势。治疗后，他们的代谢率接近正常受试者在几乎所有地区，除了额叶。持续的额叶代谢减少表现为显著的相对额叶功能减退。这些研究结果表明，在慢性精神分裂症和效用的正电子发射断层扫描在表征这些异常的异常脑功能的特定位点。
Local cerebral metabolic rates were determined by positron emission tomography and the deoxyglucose method in a group of 10 chronic schizophrenic subjects before and after somatic treatment and in eight normal subjects. Before treatment, schizophrenic subjects had markedly lower absolute metabolic activity than did normal controls in both frontal and temporal regions and a trend toward relative hyperactivity in the basal ganglia area. After treatment, their metabolic rates approached those seen in normal subjects in nearly all regions except frontal. Persistence of diminished frontal metabolism was manifested as significant relative hypofrontality. These findings suggest specific loci of aberrant cerebral functioning in chronic schizophrenia and the utility of positron emission tomography in characterizing these abnormalities.