High-pass filtering of small signals by the rod network in the retina of the toad, Bufo marinus.
High-pass filtering of small signals by the rod network in the retina of the toad, Bufo marinus.
复制标题
蟾蜍（Bufo marinus）视网膜中的杆状网络对小信号进行高通滤波。
DOI：
10.1016/s0006-3495(83)84443-9
复制
发表时间：
1983
影响因子：
3.4
通讯作者：
Owen,WG
中科院分区：
文献类型：
--
作者：
Torre,V;Owen,WG
在离体灌流的蟾蜍视网膜上，用细胞内记录的方法研究了视杆细胞光感受器网络中兴奋的电传播。用昏暗的条形闪光进行的实验表明，棒状网络对横向传播的小信号起到高通滤波器的作用。这种行为在海龟中已经被发现（Detwiler等人，1980年）。三个电气等效电路模型，可以解释这种行为被认为是和解析解的网络方程得到。通过拟合这些解析表达式的线性响应引起的微弱的闪光和电压漂移引起的外部电流注入，电路参数的值被确定。通过独立方法获得的值是一致的。然后预测了依次改变这些参数对小信号高通滤波的影响。这些预测为分析潜在机制的离子基础提供了框架，该机制将在下文中进行描述。
The electrical spread of excitation in the network of rod photoreceptors was studied by intracellular recording in the isolated, perfused retina of the toad, Bufo marinus. Experiments with dim, bar-shaped flashes of light revealed that the rod network behaves as a high-pass filter to laterally propagating small signals. Such a behavior had been found earlier in the turtle (Detwiler et al., 1980). Three electrical equivalent circuit models that can explain this behavior were considered and analytical solutions to the network equations were obtained. By fitting these analytical expressions to linear responses elicited by weak light flashes and to voltage excursions elicited by extrinsic current injections, values for the circuit parameters were determined. Values obtained by independent methods were consistent. The effects of changing each of these parameters in turn upon the high-pass filtering of small signals were then predicted. These predictions provided a framework for an analysis of the ionic basis of the underlying mechanism, which is described in the following paper.