Good Aerobic or Muscular Fitness Protects Overweight Men from Elevated Oxidized LDL
Good Aerobic or Muscular Fitness Protects Overweight Men from Elevated Oxidized LDL
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DOI：
10.1249/mss.0b013e31823822cc
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发表时间：
2012-04-01
期刊：
影响因子：
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通讯作者：
Vasankari, Tommi
中科院分区：
文献类型：
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作者：
Kosola, Jussi;Ahotupa, Markku;Vasankari, Tommi
KOSOLA，J.，M.阿霍图帕基洛莱宁Santtila和T. Vasankari。良好的有氧或肌肉健身保护超重男性从升高的氧化低密度脂蛋白。医学科学体育锻炼，第44卷，第4期，第100页。563-568，2012。氧化低密度脂蛋白（ox-LDL）与生活方式疾病有关，如心血管疾病、代谢综合征和2型糖尿病。本研究调查了ox-LDL和超重/肥胖之间的关联，以及心肺功能或肌肉健康如何影响这种关联。研究方法：健康的年轻男性（平均年龄= 25.1岁，范围= 18-48岁）（n = 831）根据体重指数（BMI）分为正常体重（n = 486），超重（n = 269）和肥胖（n = 76）组。参与者进行体能测试（最大摄氧量与自行车测力计和肌肉健康指数使用一系列的肌肉耐力测试），一般健康检查，包括血脂测定，和详细的问卷调查。根据BMI（正常与超重）和身体健康（健康三分位数：不适合，平均，适合），受试者被进一步分为六个亚组。在统计分析中使用年龄和吸烟作为协变量。结果如下：超重和肥胖组ox-LDL浓度（14%/32%）和ox-LDL/HDL胆固醇比值（32%/68%）均高于正常体重组（P < 0.005）。在BMI和心血管健康亚组中，超重/不健康亚组的ox-LDL（23%，P < 0.0001）和ox-LDL/HDL胆固醇比率（45%，P < 0.0001）高于正常体重/不健康亚组，而超重/健康和正常体重/健康受试者之间没有观察到差异。在BMI和肌适能亚组中，超重/不适能组的ox-LDL（24%，P < 0.0001）和ox-LDL/HDL胆固醇比值（51%，P < 0.0001）高于正常体重/不适能组。结论：超重和肥胖与ox-LDL脂质和血清常规脂质有关。然而，良好的心肺适应性和肌肉适应性似乎可以保护超重受试者免受致动脉粥样硬化脂质的影响。
KOSOLA, J., M. AHOTUPA, H. KYROLAINEN, M. SANTTILA, and T. VASANKARI. Good Aerobic or Muscular Fitness Protects Overweight Men from Elevated Oxidized LDL. Med. Sci. Sports Exerc., Vol. 44, No. 4, pp. 563-568, 2012. Introduction: Oxidized LDL (ox-LDL) is associated with lifestyle diseases such as cardiovascular diseases, metabolic syndrome, and type 2 diabetes. The present study investigated the association between ox-LDL and overweight/obesity and how cardiorespiratory or muscle fitness affects this association. Methods: Healthy young (mean age = 25.1 yr, range = 18-48 yr) men (n = 831) were divided into normal-weight (n = 486), overweight (n = 269), and obese (n = 76) groups according to their body mass index (BMI). The participants underwent physical fitness tests (maximal oxygen uptake with bicycle ergometer and muscle fitness index using series of muscle endurance tests), a general health examination including determination of lipid profile, and a detailed questionnaire. Subjects were further divided into six subgroups according to BM I (normal vs overweight) and physical fitness (fitness tertiles: unfit, average, fit). Age and smoking were used in the statistical analysis as covariates. Results: In overweight and obese participants, the concentrations of ox-LDL (14%/32%) and the ratio of ox-LDL/HDL cholesterol (32%/68%) were higher compared with subjects with normal weight (P < 0.005, in all). In BM I and cardiovascular fitness subgroups, ox-LDL (23%, P < 0.0001) and the ox-LDL/HDL cholesterol ratio (45%, P < 0.0001) were higher in the overweight/unfit subgroup when compared with the normal-weight/unfit subgroup, whereas no differences were observed between the overweight/fit and normal-weight/fit subjects. Among the BM I and muscle fitness subgroups, ox-LDL (24%, P < 0.0001) and the ox-LDLIHDL cholesterol ratio (51%, P < 0.0001) were higher in the overweight/unfit group compared with the normal-weight/unfit group. Conclusions: Overweight and obesity are associated with ox-LDL lipids and serum conventional lipids. However, both good cardiorespiratory fitness and muscular fitness seem to protect overweight subjects from the atherogenic lipid profile.