IgA nephropathy associated with seronegative spondylarthropathies.
IgA nephropathy associated with seronegative spondylarthropathies.
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IgA 肾病与血清阴性脊柱关节病相关。
DOI：
10.1002/art.1780250205
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发表时间：
1982
影响因子：
--
通讯作者：
D. Freeman
中科院分区：
文献类型：
--
作者：
J. Jennette;A. L. Ferguson;M. A. Moore;D. Freeman
三名血清阴性的脊椎关节病患者被发现患有IgA肾病。两名患者患有强直性脊柱炎(一名患有牛皮癣)，一名患者患有不完全性赖特氏综合征。这三人都有局灶性增生性肾小球肾炎，并有以IgA为主的系膜免疫沉积。一名患者患有白细胞破碎性脉管炎。IgA肾病与血清阴性脊柱关节病的相关性增加了共同或相关发病机制的可能性。有证据表明，这两种疾病都是通过粘膜接触病原性抗原的遗传控制免疫反应来介导的。
Three patients with a seronegative spondylarthropathy were found to have IgA nephropathy. Two patients had ankylosing spondylitis (one with psoriasis), and one had incomplete Reiter's syndrome. All three had a focal proliferative glomerulonephritis with IgA-dominant mesangial immune deposits. One patient had a leukocytoclastic vasculitis. This association of IgA nephropathy with seronegative spondylarthropathies raises the possibility of a common or related pathogenesis. There is evidence to suggest that both diseases are mediated by genetically controlled immune responses to mucosal contact with etiologic antigens.