β3 adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients
β3 adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients
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DOI：
10.1038/oby.2004.17
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Xu, XP
中科院分区：
文献类型：
--
作者：
Hao, K;Peng, SJ;Xu, XP
目的：肥胖是一种复杂的性状，受环境和遗传危险因素的影响。03肾上腺素能受体（ADRB 3）在脂肪组织中表达并在能量代谢中起作用。该基因的密码子64（W64R）上的错义突变与受体功能障碍有关。以前的研究探讨这种多态性和肥胖之间的关系产生了不一致的结果。本研究评估了W64 R基因型和肥胖相关表型之间的关联，包括体重，BMI，和血清甘油三酯，胆固醇，和glucose. Research Methods and Procedures：我们确定了ADRB 3 W64 R基因型和空腹血脂和血糖浓度为695高血压成人（336名男性，359名女性）从中国安徽省农村县。多元线性回归模型拟合检测ADRB 3基因多态性和肥胖相关表型之间的关联。结果：ADRB 3 W64 R多态性与男性体重和BMI显著相关，但在女性中不相关。在控制了潜在的混杂变量后，R64等位基因纯合子的男性比W64等位基因纯合子的男性重11.8 kg（p <0.001），BMI高3.7 kg/m2（p = 0.001）。血脂和血糖的血清浓度被发现与遗传polymorphis.Discussion：ADRB 3 R64等位基因与男性体重和BMI增加，但在女性中不相关。受试者的甘油三酯、胆固醇、血糖或血压水平未改变遗传相关性。
Objectives: Obesity is a complex trait that is affected by both environmental and genetic risk factors. The 03 adrenergic receptor (ADRB3) is expressed in adipose tissue and plays a role in energy metabolism. A missense mutation on codon 64 of this gene (W64R) is associated with receptor malfunction. Previous studies examining the relation between this polymorphism and obesity produced inconsistent findings. The current study assessed the association between the W64R genotype and obesity-related phenotypes, including body weight, BMI, and serum triglycerides, cholesterol, and glucose.Research Methods and Procedures: We determined the ADRB3 W64R genotypes and fasting serum lipid and glucose concentrations for 695 hypertensive adults (336 men, 359 women) from a rural county in Anhui Province, China. Multivariate linear regression models were fit to detect associations between the genetic polymorphism and obesity-related phenotypes.Results: The ADRB3 W64R polymorphism was significantly associated with body weight and BMI in men but not in women. After controlling for potential confounding variables, men who were homozygous for the R64 allele were 11.8 kg heavier (p < 0.001) and had a BMI that was 3.7 kg/m(2) greater (p = 0.001) than men who were homozygous for the W64 allele. Serum concentrations of lipids and glucose were found not associated with the genetic polymorphism.Discussion: The ADRB3 R64 allele was associated with increased body weight and BMI in men but not in women. The genetic association was not modified by triglyceride, cholesterol, blood glucose, or blood pressure levels of the subjects.