Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants
Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants
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DOI：
10.1203/00006450-199703000-00014
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发表时间：
1997-03-01
影响因子：
3.6
通讯作者：
Stuff, JE
中科院分区：
文献类型：
--
作者：
Abrams, SA;Wen, JP;Stuff, JE
关于可能同时接受固体食物的较大婴儿母乳中矿物质生物利用度的数据很少（beikust）。我们测量了 14 名健康、非贫血的 5-7 个月母乳喂养婴儿对 Ca、Zn 和 Fe 的吸收情况，这些婴儿的母乳被这些矿物质的稳定同位素（Ca-44、Zn-70 和 Fe-58）外在标记。此外，静脉注射 Ca 和 Zn 稳定同位素（Ca-46 和 Zn-67），另一种 Fe（Fe-57）同位素作为非餐剂量口服给药，不与食物同用。受试者没有接受任何人造婴儿配方奶粉或牛奶，但大多数（10/14）正在接受贝科斯特。使用给药后 24 小时内同位素的尿排泄量 (Ca) 或给药后 72 小时内同位素的尿比 (Zn) 计算 Ca 和 Zn 的吸收。使用 14 天时的红细胞掺入量计算铁吸收量。与母乳一起服用的 Fe-58 的铁吸收率平均为 20.7 +/- 14.8%（几何平均值为 14.8%），而非膳食剂量的 Fe-57 的铁吸收率为 17.7 +/- 15.1%（几何平均值为 11.0%）。 Ca 吸收率平均为 61.3 +/- 22.7%，Zn 吸收率（n = 10）平均为 49.5 +/- 18.5%。来自非膳食铁剂量 (Fe-57) 而非母乳 (Fe-58) 的铁吸收（自然对数）与血清铁蛋白显着负相关（r = -0.70，p = 0.007 对比 r = -0.35，p = 0.24）。在本研究的摄入水平上，每日从贝科斯特摄入的铁、钙和锌总量与其从母乳中的吸收分数没有显着相关，但从贝科斯特摄入的铁与非餐剂量铁的吸收呈显着负相关（r = -0.61，p = 0.021）。 饮食。
Data are scarce regarding mineral bioavailability from human milk in older infants who may also be receiving solid foods (beikust), We measured the absorption of Ca, Zn, and Fe in 14 healthy, nonanemic 5-7-mo-old breast-fed infants whose mothers' milk was extrinsically labeled with stable isotopes (Ca-44, Zn-70, and Fe-58) of these minerals. In addition, Ca and Zn stable isotopes (Ca-46 and Zn-67) were administered i.v., and a second isotope of Fe (Fe-57) was given orally without food as a non-meal dose. Subjects were not receiving any artificial infant formula or cow's milk, but most (10/14) were receiving beikost. Ca and Zn absorption was calculated using the urinary excretion of the isotopes during the 24 h after dosing (Ca) or their urinary ratio 72 h after dosing (Zn). Fe absorption was calculated using the red blood cell incorporation at 14 d. Fe absorption averaged 20.7 +/- 14.8% from the Fe-58 given with human milk (geometric mean, 14.8%) and 17.7 +/- 15.1% (geometric mean, 11.0%) from the Fe-57 non-meal dose. Ca absorption averaged 61.3 +/- 22.7% and Zn absorption (n = 10) averaged 49.5 +/- 18.5%. Absorption of Fe (natural logarithm) from the non-meal Fe dose (Fe-57) but not from the human milk (Fe-58) was significantly negatively correlated to serum ferritin (r = -0.70, p = 0.007 versus r = -0.35, p = 0.24). At the intake levels in this study, total daily Fe, Ca, and Zn intakes from beikost were not significantly correlated to their fractional absorption from breast milk, but Fe intake from beikost was significantly negatively correlated to absorption of Fe from the non-meal dose (r = -0.61, p = 0.021), We conclude that minerals are well absorbed from human milk in older infants after the introduction of beikost to the diet.