The renin-angiotensin system and thirst: a reevaluation.
The renin-angiotensin system and thirst: a reevaluation.
复制标题
肾素-血管紧张素系统和口渴：重新评估。
作者：
E. Stricker;W. Bradshaw;R. Mcdonald
全身注射肾素刺激肾切除大鼠大量饮酒，可产生远高于生理范围的血浆肾素活性。此外，在实验性低血压期间，肾脏完整的大鼠中血浆肾素活性的增加似乎太低，无法为观察到的水摄入量增加提供基础。这些发现质疑肾素-血管紧张素系统在正常生理条件下对口渴的贡献。
Systemic injections of renin that stimulate substantial amounts of drinking in nephrectomized rats can produce plasma renin activities that fall well above the physiological range. Furthermore, increases in plasma renin activities that occur in rats with intact kidneys during experimental hypotension appear to be too low to provide the basis for the observed elevations in water intake. These findings question the contribution of the renin-angiotensin system to thirst under normal physiological conditions.