Role of Krüppel‐like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells
Role of Krüppel‐like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells
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DOI：
10.1002/iub.298
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发表时间：
2010-02
期刊：
影响因子：
4.6
通讯作者：
Bin Zheng;Mei Han;J. Wen
中科院分区：
文献类型：
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作者：
Bin Zheng;Mei Han;J. Wen
血管平滑肌细胞(VSMCs)的表型转换和增殖是许多血管增殖性疾病发展的关键因素，如动脉粥样硬化和经皮冠状动脉介入治疗后的再狭窄。KRüppel样因子4(KLF4)在VSMC的增殖和分化中起关键作用。本文就KLF4在VSMC表型转换和增殖中的生理和病理生物学作用作一综述。©2010 IUBMB IUBMB生活，62(2)：132-139,2010
Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Krüppel‐like factor 4 (KLF4) has been shown to play a key role in VSMC proliferation and differentiation. The focus of this review is to provide an overview for understanding the physiological and pathobiological roles of KLF4 in phenotypic switching and proliferation of VSMCs. © 2010 IUBMB IUBMB Life, 62(2): 132–139, 2010