Sarin poisoning in Matsumoto, Japan
Sarin poisoning in Matsumoto, Japan
复制标题
日本松本沙林毒气中毒事件
DOI：
10.1016/s0140-6736(95)92170-2
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Mimura
中科院分区：
文献类型：
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作者：
H. Morita;N. Yanagisawa;T. Nakajima;Mikio Shimizu;H. Hirabayashi;H. Okudera;M. Nohara;Youko Midorikawa;S. Mimura
1994年6月27日，日本松本市的一个住宅区发生了一起疑似沙林恐怖袭击，大约600名居民和救援人员中毒； 58人被送往医院，7人死亡。我们检查了 264 名寻求治疗的人的临床和实验室检查结果以及中毒 3 周后对 155 名居民进行的健康检查结果。严重中毒者的血清胆碱酯酶、红细胞乙酰胆碱酯酶、血清甘油三酯、血清钾和氯化物下降；血清肌酸激酶、白细胞和尿液中的酮体增加。轻微发烧和脑电图癫痫样异常持续长达 30 天。检查未发现任何人有持续的异常身体发现。所有接受检查的人的乙酰胆碱酯酶在 3 个月内恢复正常。尽管暴露后30天出现亚临床性瞳孔缩小和神经病变，但大多数人接触沙林后几乎所有症状都迅速消失，并且没有留下任何后遗症。
A presumed terrorist attack with sarin occurred in a residential area of the city of Matsumoto, Japan, on June 27, 1994. About 600 residents and rescue staff were poisoned; 58 were admitted to hospitals, and 7 died. We examined clinical and laboratory findings of 264 people who sought treatment and the results of health examinations on 155 residents done 3 weeks after the poisoning. Findings for severely poisoned people were decreases in serum cholinesterase, acetylcholinesterase in erythrocytes, serum triglyceride, serum potassium and chloride; and increases in serum creatine kinase, leucocytes, and ketones in urine. Slight fever and epileptiform abnormalities on electroencephalogram were present for up to 30 days. Examination revealed no persisting abnormal physical findings in any individual. Acetylcholinesterase returned to normal within 3 months in all people examined. Although subclinical miosis and neuropathy were present 30 days after exposure, almost all symptoms of sarin exposure disappeared rapidly and left no sequelae in most people.