Drug seeking becomes compulsive after prolonged cocaine self-administration
Drug seeking becomes compulsive after prolonged cocaine self-administration
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DOI：
10.1126/science.1098975
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发表时间：
2004-08-13
期刊：
影响因子：
56.9
通讯作者：
Everitt, BJ
中科院分区：
文献类型：
--
作者：
Vanderschuren, LJMJ;Everitt, BJ
面对不良后果的强迫性药物使用是成瘾的一个标志性特征，但几乎没有临床前证据表明从偶然到强迫性药物使用的实际进展。介绍了一个令人厌恶的条件刺激抑制药物寻求有限的可卡因自我管理经验的大鼠，但不再这样做后，延长可卡因服用史。与此相反，在等效延长蔗糖经验，蔗糖寻求仍然抑制了一个令人厌恶的条件刺激。长期服用可卡因后，在环境逆境信号的存在下持续寻求可卡因并不是因为恐惧条件反射受损，也不是因为可卡因的激励价值增加，可能反映了强迫行为的建立。
Compulsive drug use in the face of adverse consequences is a hallmark feature of addiction, yet there is little preclinical evidence demonstrating the actual progression from casual to compulsive drug use. Presentation of an aversive conditioned stimulus suppressed drug seeking in rats with limited cocaine self-administration experience, but no longer did so after an extended cocaine-taking history. In contrast, after equivalent extended sucrose experience, sucrose seeking was still suppressed by an aversive conditioned stimulus. Persistent cocaine seeking in the presence of signals of environmental adversity after a prolonged cocaine-taking history was not due to impaired fear conditioning, nor to an increase in the incentive value of cocaine, and may reflect the establishment of compulsive behavior.