Implications for changes in Anopheles darlingi biting behaviour in three communities in the peri-Iquitos region of Amazonian Peru
Implications for changes in Anopheles darlingi biting behaviour in three communities in the peri-Iquitos region of Amazonian Peru
复制标题
DOI：
10.1186/s12936-015-0804-2
复制
发表时间：
2015-07-30
期刊：
影响因子：
3
通讯作者：
Conn, Jan E.
中科院分区：
文献类型：
--
作者：
Moreno, Marta;Saavedra, Marlon P.;Conn, Jan E.
背景资料：秘鲁亚马逊河流域伊基托斯周围地区的疟疾传播被定为季节性和低度地方性的，最近还描述了高度地方性热点。尽管长效驱虫蚊帐的分发时间相对较晚，但疟疾在亚马孙秘鲁地区依然存在，2014年与往年相比大幅增加。达氏按蚊，确定为主要的疟疾媒介，是众所周知的，其可变的行为取决于地方和environment.Methods：要评估有关季节性和疟疾传播的媒介生物学指标，蚊子收集在三个地方进行了在周围伊基托斯地区，洛雷托，秘鲁在2011-2012年。人类登陆渔获物（HLC）收集方法，香农（SHA）和CDC陷阱类型进行了比较，在新热带环境的有效性。Ababelos，人类叮咬率和昆虫接种率（EIR）进行了测量，提供一个更新的视图后LLIN distribution.Results的传输模式：HLC收集显着更多的按蚊比SHA和CDC灯陷阱。达氏按蚊是所有三个村庄中最流行的物种（84%）。叮咬模式因陷阱类型、季节和村庄而异。EIR在时间（月）和空间上变化，最高值（2.52）发生在2012年Cahuide疟疾暴发期间。出乎意料的是，在正常的疟疾传播季节之外，感染率很高（1.47和1.75），与Cahuide的第二次地方疫情相吻合。第一次鉴定的按蚊dunhami和按蚊oswaldoi C在秘鲁，使用分子标记，也在本study.Conclusion：这些数据强调了HLC作为最有意义的收集方法测量媒介生物学指标在这一地区的重要性。最高的每月EIR提供了额外的证据，季节性传播的河流地区与高河流水位，和一个。Darlingi是唯一的传播贡献者。户外叮咬和傍晚受感染蚊子增加的趋势可能会破坏长效驱虫蚊帐作为疟疾主要干预措施的有效性。
Background: Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantially in 2014 compared to previous years. Anopheles darlingi, identified as the main malaria vector, is known for its variable behaviour depending on locality and environment.Methods: To evaluate vector biology metrics in relation to seasonality and malaria transmission, mosquito collections were carried out in three localities in the peri-Iquitos region, Loreto, Peru in 2011-2012. Human landing catch (HLC) collection method, Shannon (SHA) and CDC trap types were compared for effectiveness in a neotropical setting. Abundance, human biting rate and entomological inoculation rate (EIR) were measured to provide an updated view of transmission patterns post-LLIN distribution.Results: HLC collected significantly more anopheline mosquitoes than SHA and CDC light traps. Anopheles darlingi was the most prevalent species in all three villages (84% overall). Biting patterns varied depending on trap type, season and village. EIR varied temporally (monthly) and spatially and the highest (2.52) occurred during the 2012 malaria outbreak in Cahuide. Unexpectedly there was a high infection rate (1.47 and 1.75) outside the normal malaria transmission season, coincident with a second local outbreak in Cahuide. The first identification of Anopheles dunhami and Anopheles oswaldoi C in Peru, using molecular markers, is also reported in this study.Conclusion: These data underscore the importance of HLC as the most meaningful collection method for measuring vector biology indices in this region. The highest monthly EIR provides additional evidence of seasonal transmission in riverine localities correlated with high river levels, and An. darlingi as the only contributor to transmission. The trend of an increase in outdoor-biting together with early-evening infected mosquitoes may undermine the effectiveness of LLINs as a primary malaria intervention.