Levo-tetrahydropalmatine decreases ethanol drinking and antagonizes dopamine D2 receptor-mediated signaling in the mouse dorsal striatum.
Levo-tetrahydropalmatine decreases ethanol drinking and antagonizes dopamine D2 receptor-mediated signaling in the mouse dorsal striatum.
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DOI：
10.1016/j.bbr.2013.01.028
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发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Choi, Doo-Sup
中科院分区：
文献类型：
--
作者：
Kim, Taehyun;Hinton, David J.;Johng, Sandy;Wang, Jia Bei;Choi, Doo-Sup
An herb derived compound, levo-tetrahydropalmatine (L-THP), attenuates self-administration of cocaine and opiates in rodents. Since L-THP mainly antagonizes dopamine D2 receptors (D2R) in the brain, it is likely to regulate other addictive behaviors as well. Here, we examined whether L-THP regulates ethanol drinking in C57BL/6J mice using a two-bottle choice drinking experiment. L-THP treated mice consumed less ethanol compared to vehicle-treated mice during the 15% ethanol drinking session while water consumption remained similar between each group. We then examined the molecular basis underlying the pharmacological effect of L-THP in mice. Our results indicated that a single injection L-THP increased active phosphorylated forms of PKA, AKT and ERK in the caudate-putamen (CPu), but not in the nucleus accumbens (NAc), of alcohol naïve mice. Interestingly, we found that systematic treatment with L-THP for 4 consecutive days while mice were drinking 15% ethanol increased pPKA levels in the CPu, but not in the NAc. In contrast to the effect of acute L-THP treatment, no differences were detected for pAKT or pERK in either striatal regions. Together, our findings suggest that reduction of ethanol drinking by L-THP treatment is possibly correlated with D2R-mediated PKA signaling in the CPu.
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影响因子：
10.6
作者：
Neasta, Jeremie;Ben Hamida, Sami;Yowell, Quinn V.;Carnicella, Sebastien;Ron, Dorit
通讯作者：
Ron, Dorit
影响因子：
10.6
作者：
Nam, Hyung Wook;Lee, Moonnoh R.;Choi, Doo-Sup
通讯作者：
Choi, Doo-Sup
影响因子：
6.1
作者：
STOOF, JC;KEBABIAN, JW
通讯作者：
KEBABIAN, JW
影响因子：
5
作者：
Liu, Yan-Li;Yan, Ling-Di;Gong, Ze-Hui
通讯作者：
Gong, Ze-Hui
影响因子：
5.7
作者：
Lai, Chih-Chia;Kuo, Ting-In;Lin, Hsun-Husn
通讯作者：
Lin, Hsun-Husn