Male sex determination in the spiny rat Tokudaia osimensis (Rodentia: Muridae) is not Sry dependent
Male sex determination in the spiny rat Tokudaia osimensis (Rodentia: Muridae) is not Sry dependent
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DOI：
10.1007/s003359900823
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发表时间：
1998-07-01
期刊：
影响因子：
2.5
通讯作者：
Laudet, V
中科院分区：
文献类型：
--
作者：
Soullier, S;Hanni, C;Laudet, V
在哺乳动物中，性别从胚胎性腺如睾丸或卵巢的发育开始，并受基因控制。在男性中，睾丸发育依赖于Y染色体编码的Sry基因的遗传。由于转基因实验的结果，人们认为Sry是唯一编码在Y染色体上的基因，它是将生殖器脊转向睾丸发育途径所必需的（Koopman et al. 1990）。最近的一份报告描述了这一规则的一个例外，该报告描述了两种具有非常规性体补体的arvicoline啮齿动物Ellobius中Sry的缺失（Just et al. 1995）。在这种情况下，Tokudaia osimensis osimensis，一种来自奄美岛（日本南部琉球群岛的一部分）的小型鼠类啮齿动物，是一种有趣的哺乳动物。事实上，在这个特殊的物种，琉球刺鼠，雄性和雌性具有相同的核型（2n 25， XO; Honda et al. 1977）。这种小刺鼠（头部和身体长度从12到18厘米）是一种罕见的哺乳动物（诺瓦克1991年），世界自然保护联盟（1978年）认为，由于琉球群岛自然弧的普遍破坏，这种小刺鼠严重濒危。在日本，Tokudaia osimensis受到全面保护。因此，对这种哺乳动物的X染色体或其中一个常染色体上是否存在Sry进行了研究。
In mammals, gender follows from the development of the embryonic gonads as testis or ovaries and is under genetic control. In males, testis development is dependent on the inheritance of the Y Chromosome-encoded Sry gene. It is believed, as a result of transgenic experiments, that Sry is the only gene encoded on the Y Chr that is necessary to switch the genital ridges towards the testicular developmental pathway (Koopman et al. 1990). An exception to this rule is described in a recent report describing the absence of Sry in two species of an arvicoline rodent, Ellobius, which have an unconventional gonosome complement (Just et al. 1995).In this context, Tokudaia osimensis osimensis, a small murine rodent from the Amami Island (part of the Ryukyu Archipelago in the south of Japan), is an intriguing mammal. Indeed, in this particular species, the Ryukyu Spiny Rat, males and females have an identical karyotype (2n 25, XO; Honda et al. 1977). This small (head and body length from 12 to 18 cm) spiny rat is a rare mammal (Nowak 1991), believed by IUCN (1978) to be seriously endangered by the general destruction of natural arcas on the Ryukyu Islands. Tokudaia osimensis is fully protected in Japan. The presence or the absence of Sry on either the X Chr or on one of the autosomes of this particular mammal was, therefore, investigated.