Macrocephaly in children and adults with autism
Macrocephaly in children and adults with autism
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DOI：
10.1097/00004583-199702000-00019
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发表时间：
1997-02-01
影响因子：
13.3
通讯作者：
Folstein, SE
中科院分区：
文献类型：
--
作者：
Lainhart, JE;Piven, J;Folstein, SE
目的：探讨自闭症患者巨头畸形的发生频率和发病率及其与临床特征的关系。方法：对社区自闭症儿童和成人样本中的出生时、幼儿期和检查时的头围进行研究。作者调查了检查时的头围是否与临床特征相关。结果：14% 的自闭症受试者患有大头畸形：男性为 11%，女性为 24%。大多数人出生时并不存在大头畸形。有些人在童年早期和中期由于头部生长速度加快而变得明显。注意到头围百分位与自闭症不太严重的核心特征之间存在很小的关系。大头畸形和头围百分位均与自闭症受试者的非语言智商、语言状态、癫痫发作、神经软体征或轻微身体异常相关。结论：大头畸形在自闭症患者中很常见，通常在出生时不存在。一些（37%）自闭症儿童在幼儿期和中期的头部生长速度可能异常。大头畸形并没有根据临床特征定义自闭症个体的同质亚组。
Objective: To explore the frequency and onset of macrocephaly in autism and its relationship to clinical features.Method: Head circumferences at birth, during early childhood, and at the time of examination were studied in a community-based sample of autistic children and adults. The authors investigated whether head circumference at the time of examination was associated with clinical features.Results: Fourteen percent of the autistic subjects had macrocephaly: 11% of males and 24% of females. In most, the macrocephaly was not present at birth; in some it became apparent in early and middle childhood as a result of increased rate of head growth. A small relationship was noted between head circumference percentile and less severe core features of autism. Neither macrocephaly nor head circumference percentile was associated with nonverbal IQ, verbal status, seizure disorder, neurological soft signs, or minor physical anomalies in the autistic subjects.Conclusion: Macrocephaly is common in autism and usually is not present at birth. Rates of head growth may be abnormal in early and middle childhood in some (37%)' children with autism. Macrocephaly does not define a homogeneous subgroup of autistic individuals according to clinical features.