Microelectrode Study of Delayed Conduction in the Canine Right Bundle Branch
Microelectrode Study of Delayed Conduction in the Canine Right Bundle Branch
复制标题
犬右束支延迟传导的微电极研究
DOI：
10.1161/01.res.23.6.753
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发表时间：
1968
影响因子：
20.1
通讯作者：
D. Brody
中科院分区：
文献类型：
--
作者：
J. Wennemark;V. Ruesta;D. Brody
对 30 只大型杂种狗的半隔离右束支进行了传导延迟的电生理学研究。延迟是通过向束支外部施加阻电电流而产生的。使用玻璃毛细管微电极的多次记录揭示了与延迟现象相关的两种基本偏转。初始或前导偏转源自块的近端或前缘，并随着电压和上升速度的逐渐衰减而快速地通过块传输。第二个或尾部偏转源自块的远端或后缘的再生响应，并快速逆行传输到块中，同时电压和上升速度逐渐衰减。所传输的电位本质上似乎是电紧张的。主要偏转似乎是通过块保持 1:1 传导比的传输事件。然后，延迟的幅度与该偏转达到阈值电势并在块的尾部部分中启动再生响应所需的时间相关，在该部分中，细胞受阻塞电流的影响较小。
The electrophysiology of conduction delay was investigated in the semi-isolated right bundle branch of 30 large mongrel dogs. Delay was produced by the external application of an electric blocking current to the bundle branch. Multiple recordings with glass capillary microelectrodes revealed two basic deflections associated with the delay phenomenon. An initial, or leading, deflection originated from the proximal or leading edge of the block and was rapidly transmitted through the block with progressive decay of voltage and rise velocity. A second, or trailing, deflection originated from the regenerative response at the distal or trailing edge of the block and was rapidly transmitted retrograde into the block, with progressive decay of voltage and rise velocity. The transmitted potentials appeared to be electrotonic in nature. The leading deflection appeared to be the transmitted event which maintained a conduction ratio of 1:1 through the block. The magnitude of delay was then related to the time required for this deflection to reach the threshold potential and initiate a regenerative response in the trailing portion of the block where the cells were less affected by the blocking current.