Low serum biotin levels in Japanese children fed with hydrolysate formulas.
Low serum biotin levels in Japanese children fed with hydrolysate formulas.
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使用水解产物配方奶粉喂养的日本儿童的血清生物素水平较低。
DOI：
10.1111/ped.12937
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Mimaki M
中科院分区：
文献类型：
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作者：
Sato Y;Wakabayashi K;Ogawa E;Motoyama K;Kodama H;Kobayashi S;Mimaki M
背景鉴于日本婴儿的营养性生物素缺乏已被报道，一个简单的方法来估计生物素水平是必要的。使用抗生物素蛋白结合测定法测量婴儿配方奶粉、母乳和用各种类型配方奶粉喂养的婴儿的血清中的生物素含量。方法使用市售的ELISA试剂盒测量54种类型配方奶粉中的生物素，包括用于牛奶过敏的水解物配方奶粉，以及在母乳和27名婴儿的血清中喂养这些formuls.ResultsThe生物素含量达到推荐值，只有五个配方。所有水解产物配方和超过一半的特殊配方含有<0.1 μg/dL的生物素。血清生物素是低的婴儿喂养的水解物配方，其中一个脱发相关的生物素deficiency.ConclusionWhile许多是无症状的，婴儿喂养的配方缺乏生物素是在发展有症状的疾病的风险。2014年年中，母乳代用品中添加生物素的做法最终获得批准，但日本的儿科医生仍应警惕婴儿营养性生物素缺乏症。
BackgroundGiven that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin‐binding assay.MethodsA commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas.ResultsThe biotin content reached the recommended value in only five formulas. All of the hydrolysate formulas and more than half of the special formulas contained biotin <0.1 μg/dL. Serum biotin was low in infants fed only with the hydrolysate formulas, and one of them had alopecia related to biotin deficiency.ConclusionWhile many were asymptomatic, infants fed with formulas lacking biotin are at risk of developing symptomatic disease. The addition of biotin to breast milk substitutes was finally approved in the middle of 2014, however pediatricians in Japan should still be vigilant with regard to nutritional biotin deficiency in infants for the time being.