STUDIES ON CONTROL OF ANTIBODY SYNTHESIS - INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON IMMUNE RESPONSE
STUDIES ON CONTROL OF ANTIBODY SYNTHESIS - INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON IMMUNE RESPONSE
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DOI：
10.1084/jem.126.1.81
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发表时间：
1967-01-01
影响因子：
15.3
通讯作者：
SISKIND, GW
中科院分区：
文献类型：
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作者：
BRODY, NI;WALKER, JG;SISKIND, GW
使用 2 个半抗原决定簇（二硝基苯基 (DNP-) 和砷 (R-Azo-)）研究了被动抗体对抗原竞争和抗体形成的抑制。发现无论半抗原在相同的载体分子上还是在不同的载体分子上，抗原竞争的程度相同。当 2 种半抗原位于单独的载体分子上时，通过施用对该决定簇特异的被动抗体来抑制针对该决定簇的活性抗体形成，部分消除了抗原竞争的抑制作用；但当两个决定簇存在于同一分子上时，对第二个半抗原的抗体产生没有影响。被动抗体抑制主动抗体形成的机制是通过循环抗体与细胞竞争可用抗原。从抑制机制、抗原竞争和抗体形成的控制方面讨论了结果。
Antigenic competition and suppression of antibody formation by passive antibody were studied using 2 haptenic determinants (dinitrophenyl (DNP-) and arsenilic (R-Azo-)). Antigenic competition was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of active antibody formation to 1 determinant by administration of passive antibody specific for that determinant partially eliminated the depressive effects of antigenic competition when the 2 haptens were on separate carrier molecules; but had no effect on antibody production to the 2nd hapten when the 2 determinants were present on the same molecule. The mechanism by which passive antibody suppresses active antibody formation is by competition of circulating antibody with cells for available antigen. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.