Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro.
Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro.
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DOI：
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发表时间：
2007
影响因子：
0.4
通讯作者：
T. Tanaka;K. Yukawa;N. Umesaki
中科院分区：
文献类型：
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作者：
T. Tanaka;K. Yukawa;N. Umesaki
本研究旨在探讨卡铂（CBDCA）、奈达铂（NEP）等顺铂以外的铂类抗癌药物在宫颈鳞癌患者放化疗中的有效应用。材料与方法以放射性敏感的人宫颈鳞癌细胞系ME180为材料，研究辐射对细胞CBDCA和NEP敏感性的影响。结果辐照显著降低细胞对CBDCA的敏感性。同时照射的细胞与CBDCA照射前8 h和照射后8 h的细胞之间CBDCA敏感性无显著变化。辐照前后8 h处理的细胞对NEP的敏感性明显高于同时辐照的细胞。结论：虽然同时照射细胞的CBDCA敏感性降低，但照射增强了NEP敏感性。因此，NEP，而不是CBDCA，可能是宫颈癌同步放化疗的候选抗癌药物。为获得最佳效果，应在照射前或照射后几小时给药。
BACKGROUND The study was performed to examine how the platinum anticancer drugs other than cisplatin, such as carboplatin (CBDCA) and nedaplatin (NEP) can be effectively used in chemoradiotherapy for cervical squamous cell carcinoma patients. MATERIALS AND METHODS The radiosensitive human cervical squamous cell carcinoma cell line ME180 was examined to investigate the radiation effects on CBDCA and NEP sensitivities of the cells. RESULTS Irradiation significantly reduced cellular CBDCA sensitivity. There were no significant changes in CBDCA sensitivity between the cells concurrently irradiated and those treated with CBDCA 8 h before or 8 h after irradiation. However NEP sensitivity of the cells treated 8 h before or 8 h after irradiation was significantly higher than that in cells concurrently irradiated. CONCLUSIONS Although CBDCA sensitivity in the concurrently irradiated cells is reduced, NEP sensitivity is enhanced by irradiation. NEP, but not CBDCA, therefore, may be a candidate anticancer drug for concurrent chemoradiotherapy for cervical cancer. For the greatest efficacy, NEP should be administered to patients several hours before or after irradiation.