EFFECTS OF AN ORAL GLUCOSE-LOAD ON PLASMA NEUROTRANSMITTERS IN HUMANS - INVOLVEMENT OF REM-SLEEP
EFFECTS OF AN ORAL GLUCOSE-LOAD ON PLASMA NEUROTRANSMITTERS IN HUMANS - INVOLVEMENT OF REM-SLEEP
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DOI：
10.1159/000118889
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发表时间：
1992-01-01
影响因子：
3.2
通讯作者：
JIMENEZ, V
中科院分区：
文献类型：
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作者：
LECHIN, F;VANDERDIJS, B;JIMENEZ, V
研究人员在 100 名正常人口服葡萄糖 (OGTT) 之前和之后测量了血浆去甲肾上腺素 (NA)、肾上腺素 (Ad)、多巴胺 (DA)、血小板血清素 (p5HT)、游离血清素 (f5HT)、血糖、心率 (HR) 和血压 (BP)。每名受试者在 OGTT 前 2-3 周进行一次假喂养测试。除了葡萄糖升高外，NA、p5HT 和 NA/Ad 比率也显着增加。 Ad、DA、f5HT、HR 和 BP 平均值 +/- SE 值未观察到显着变化。 90 分钟和 180 分钟时，NA/p5HT、Ad/p5HT 和 DA/p5HT 比率平均值显着降低。在血浆神经递质之间发现了几种显着的相关性。当将 NA、Ad 和 DA 与它们各自相对于 p5HT 的比率作图时，获得了非常高的正相关性；然而，它们 (r = 0.99) 在 90 分钟和 180 分钟时显着下降。根据对这些结果的评估，我们推断在 OGTT 期间肾上腺发生静止。在这种情况下，血浆神经递质受到中枢双极系统的控制：去甲肾上腺素能-副交感神经。所有数值数据强烈表明，去甲肾上腺素能系统在 60、120 和 2 1 0 分钟时占主导地位，而副交感神经系统在 90 和 180 分钟时占主导地位。后者受到阿托品干扰的事实强化了这一假设。相关性分析还表明，DA 和 p5HT 可能充当缓冲剂并调节 OGTT 期间记录的 NA 血浆水平的过度增加。
Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. Aside from glucose rise, significant increases in NA, p5HT and the NA/Ad ratio were registered. No significant changes were observed in Ad, DA, f5HT, HR and BP mean +/- SE values. Significant reductions in the NA/p5HT, Ad/p5HT and DA/p5HT ratios' mean values were registered at 90 and 180 min. Several significant correlations were found amongst plasma neurotransmitters. Very high positive correlations were obtained when NA, Ad and DA were plotted against the ratio of each one of them over p5HT; however, they (r = 0.99) decreased significantly at 90 and 180 min. Upon evaluation of these results we infer that quiescence of adrenal glands occurs during OGTT. Under such circumstances, plasma neurotransmitters are left under the control of a central bipolar system: noradrenergic-parasympathetic. All numerical data strongly suggest that the noradrenergic system predominates at 60, 120 and 2 1 0 min, whereas parasympathetic predominance occurs at 90 and 180 min. The fact that the latter is interfered by atropine reinforces this hypothesis. Analyses of correlations also suggest that DA and p5HT probably act as a buffer and modulate the excessive increase in NA plasma levels registered during OGTT.