Screening of chemical compound libraries identified new anti-Toxoplasma gondii agents
Screening of chemical compound libraries identified new anti-Toxoplasma gondii agents
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DOI：
10.1007/s00436-017-5698-1
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发表时间：
2018-02-01
影响因子：
2
通讯作者：
Kato, Kentaro
中科院分区：
文献类型：
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作者：
Adeyemi, Oluyomi Stephen;Sugi, Tatsuki;Kato, Kentaro
弓形虫是弓形虫病的病原体，弓形虫病是一种常见的寄生虫病，影响近三分之一的人口。原发性感染在健康个体中可以是无症状的，但在免疫功能低下的个体中可能是致命的。弓形虫病患者可用的治疗选择有限，这突出表明迫切需要确定和开发新的治疗方法。化学化合物库的无偏见筛选，包括充分表征的化合物的再利用，正在成为实现这一目标的可行方法。在目前的研究中，我们筛选了天然产物和FDA批准的化合物库，以确定那些抑制T。弓形虫生长我们鉴定了32种新的化合物，有效地抑制T。弓形虫生长我们的研究结果是新的和有前途的，并进一步加强了药物再利用的前景，以及作为替代抗寄生虫治疗剂的可行来源的各种化合物的筛选。
Toxoplasma gondii is the etiological agent of toxoplasmosis, a common parasitic disease that affects nearly one-third of the human population. The primary infection can be asymptomatic in healthy individuals but may prove fatal in immunocompromised individuals. Available treatment options for toxoplasmosis patients are limited, underscoring the urgent need to identify and develop new therapies. Non-biased screening of libraries of chemical compounds including the repurposing of well-characterized compounds is emerging as viable approach to achieving this goal. In the present investigation, we screened libraries of natural product and FDA-approved compounds to identify those that inhibited T. gondii growth. We identified 32 new compounds that potently inhibit T. gondii growth. Our findings are new and promising, and further strengthen the prospects of drug repurposing as well as the screening of a wide range of chemical compounds as a viable source of alternative anti-parasitic therapeutic agents.