A new approach to solution-phase gold seeding for SERS substrates.
A new approach to solution-phase gold seeding for SERS substrates.
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SERS底物的一种新方法来解决溶液 - 相金。
DOI：
10.1002/smll.201001836
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发表时间：
2011-02-18
期刊：
影响因子：
13.3
通讯作者：
Dai, Hongjie
中科院分区：
文献类型：
--
作者：
Tabakman, Scott M.;Chen, Zhuo;Casalongue, Hernan Sanchez;Wang, Hailiang;Dai, Hongjie
与传统的拉曼散射相比，表面增强拉曼散射(SERS)极大地提高了信噪比，使基于拉曼散射的灵敏分析成为现实。然而，到目前为止，制备高度稳定的SERS活性金衬底需要复杂而昂贵的方法和仪器。在这里，我们介绍了一种通用的、完全溶液相的、基于种子的方法，能够在各种衬底上制备用于表面增强拉曼散射(SERS)应用的金膜，而不需要表面修饰或功能化。观察了∼-107的表面增强因子。此外，首次展示了在高度复杂的表面上沉积溶液相金薄膜，例如蛋白质包被的生物测定。将包被表面增强拉曼散射活性金膜的蛋白质生物测定与生物偶联的单壁碳纳米管拉曼标记相结合，实现了对血清中癌胚抗原这一肿瘤生物标志物的高灵敏度检测，检测限为∼5 FM(1pg/mL)。
Surface-enhanced Raman scattering (SERS) vastly improves signal-to-noise ratios compared to traditional Raman scattering, making sensitive assays based upon Raman scattering a reality. However, to date, preparation of highly stable SERS-active gold substrates requires complicated and expensive methodologies and instrumentation. Here, we introduce a general and completely solution phase, seed-based approach, capable of producing gold films for surface-enhanced Raman scattering (SERS) applications on a variety of substrates, not requiring surface modification or functionalization. SERS enhancement factors of ∼107 were observed. Moreover, solution-phase gold film deposition on highly complex surfaces, such as protein-coated bioassays, is demonstrated for the first time. Protein bioassays coated with such SERS-active gold films were combined with bioconjugated single-walled carbon nanotube Raman labels, affording high sensitivity detection of the cancer biomarker, carcinoembryonic antigen in serum, with a limit of detection of ∼5 fM (1 pg / mL).
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影响因子：
4
作者：
Chaney, SB;Shanmukh, S;Zhao, YP
通讯作者：
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影响因子：
45.3
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通讯作者：
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