Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.
Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.
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DOI：
10.1016/j.immuni.2022.01.017
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发表时间：
2022-03-08
期刊：
影响因子：
32.4
通讯作者：
Harker JA
中科院分区：
文献类型：
--
作者：
Vijayakumar B;Boustani K;Ogger PP;Papadaki A;Tonkin J;Orton CM;Ghai P;Suveizdyte K;Hewitt RJ;Desai SR;Devaraj A;Snelgrove RJ;Molyneaux PL;Garner JL;Peters JE;Shah PL;Lloyd CM;Harker JA
一些急性COVID-19住院患者的呼吸道症状持续数月。我们描绘了健康对照和出院后3至6个月的COVID-19患者的气道和外周血中的免疫蛋白质组学景观。COVID-19后患者显示出异常的气道（而非血浆）蛋白质组，与健康个体相比，与细胞凋亡、组织修复和上皮损伤相关的蛋白质浓度升高。细胞毒性淋巴细胞的数量增加，观察到个人更大的气道功能障碍，而增加B细胞数量和改变单核细胞亚群与更广泛的肺异常。对一些COVID-19后患者的一年随访表明，这些异常随着时间的推移而消退。总之，COVID-19导致持续性肺部疾病患者气道免疫格局发生长期变化，细胞死亡和组织修复的证据与细胞毒性T细胞的持续激活有关。新型冠状病毒感染后的气道，但不是血液，显示免疫和蛋白质组学变化不同的COVID-19后肺部异常与不同的免疫学特征相关BAL细胞毒性T细胞增加与上皮损伤和气道疾病相关BAL髓细胞和B细胞数量与肺部CT异常程度相关许多从急性SARS-CoV中恢复的个体-2例感染者在病毒清除后会出现持续数月至数年的呼吸功能障碍。Vijayakumar，Boustani，Ogger，Papadaki等人显示感染后3-6个月持续症状的个体具有改变的气道免疫细胞景观和持续肺损伤的证据。重要的是，不同的免疫细胞类型与正在进行的呼吸道疾病的不同方面的严重程度相关。
Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airways and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with an elevated concentration of proteins associated with apoptosis, tissue repair, and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. A one-year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to the ongoing activation of cytotoxic T cells. Post-COVID-19 airways, but not blood, show immune and proteomic changes Different post-COVID-19 lung abnormalities relate to distinct immunological features Increased BAL cytotoxic T cells are linked to epithelial damage and airway disease BAL myeloid and B cell numbers correlate with the degree of lung CT abnormality Many individuals recovering from acute SARS-CoV-2 infection suffer prolonged respiratory dysfunction for months to years after viral clearance. Vijayakumar, Boustani, Ogger, Papadaki et al. Show that individuals with persistent symptoms 3–6 months after infection have an altered airway immune cell landscape and evidence of ongoing lung damage. Importantly, different immune cell types correlate with the severity of distinct aspects of ongoing respiratory disease.
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影响因子：
64.8
作者：
Boyd DF;Allen EK;Randolph AG;Guo XJ;Weng Y;Sanders CJ;Bajracharya R;Lee NK;Guy CS;Vogel P;Guan W;Li Y;Liu X;Novak T;Newhams MM;Fabrizio TP;Wohlgemuth N;Mourani PM;PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators;Wight TN;Schultz-Cherry S;Cormier SA;Shaw-Saliba K;Pekosz A;Rothman RE;Chen KF;Yang Z;Webby RJ;Zhong N;Crawford JC;Thomas PG
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1164/rccm.202002-0460oc
发表时间：
2021-02-01
影响因子：
24.7
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Invernizzi R;Wu BG;Barnett J;Ghai P;Kingston S;Hewitt RJ;Feary J;Li Y;Chua F;Wu Z;Wells AU;George PM;Renzoni EA;Nicholson AG;Rice A;Devaraj A;Segal LN;Byrne AJ;Maher TM;Lloyd CM;Molyneaux PL
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10.1165/rcmb.2020-0387oc
发表时间：
2021-06-01
影响因子：
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作者：
Ali, Mohamed F.;Egan, Ashley M.;Carmona, Eva M.
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