Free Radicals as Mediators of Tissue Injury
Free Radicals as Mediators of Tissue Injury
复制标题
自由基作为组织损伤的介质
DOI：
10.1007/978-1-4612-0419-0_2
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
D. English
中科院分区：
文献类型：
--
作者：
J. McCord;K. Wong;Stokes Sh;W. F. Petrone;D. English
自由基机制与许多疾病状态有关，如炎症、缺血再灌注损伤、肿瘤和衰老。阐明个体自由基介导组织损伤的机制将进一步加深我们对正常发育和疾病的理解。本文综述的重点是：(1)确定几种疾病状态下自由基的来源；(2)评估运行的酶和非酶系统；(3)综述自由基损伤的研究进展。
Free radical mechanisms have been associated with a large number of disease states, such as, inflammation, ischemiareperfusion injury, neoplasia, and aging. The elucidation of the mechanisms by which individual free radical species mediate tissue injury will further our understanding of both normal development and disease. The foci of this review are to: (1) identify the sources of free radicals in a number of disease states; (2) assess the enzymatic and nonenzymatic systems operative; and (3) review the free radical induced injury seen.