In what extent anemia coexists with cognitive impairment in elderly: a cross-sectional study in Greece.
In what extent anemia coexists with cognitive impairment in elderly: a cross-sectional study in Greece.
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DOI：
10.1186/1471-2296-2-5
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发表时间：
2001
影响因子：
2.9
通讯作者：
Lionis C
中科院分区：
文献类型：
--
作者：
Argyriadou S;Vlachonikolis I;Melisopoulou H;Katachanakis K;Lionis C
开展了一个旨在研究希腊北部克里斯苏波利斯健康中心 (HCCh) 服务区痴呆症和抑郁症发生率的项目。本文报告了这项希腊研究中老年参与者中 AD 和贫血之间的关联。符合资格的参与者是 65 岁或以上的人，并且 (a) 居住在敬老院（包括所有 48 名受试者）； (b) 在 20 个工作日期间访问老年人开放中心（75 名受试者）以及 (c) 前往 HCCh 进行常规医疗护理。简易精神状态检查（MMSE）用于评估参与者的认知能力。抽血测定血清血细胞比容、维生素 B12 和叶酸。贫血和非贫血男性中可能存在认知障碍的患病率分别为 55.6% 和 34.4% (X2 = 5.8, d.f. = 1, p = 0.016)。女性中相应的比例为 47.5% 和 40.1% (X2 = 1.1, d.f. = 1, p = 0.305)。使用逻辑回归分析，年龄组（≥ 80 岁）、机构类型、维生素 B12 和贫血与可能的认知障碍存在显着的独立关联。贫血是老年人的常见症状，可能是痴呆症的危险因素，但认知障碍恶化的程度或与 AD 的关系尚不清楚。全科医生应该意识到这种共存，并建议对老年人进行筛查、检测和治疗。
A project aimed at studying the frequency of dementia and depression in the catchment area of the Health Centre of Chrissoupolis (HCCh), Northern Greece, was carried out. This paper reports the association between AD and anemia among the elderly participants in this Greek study. Eligible participants were people 65 years or over who were (a) living in the Elderly People's Home (all 48 subjects included); (b) visiting the Open Center for Elderly People during a 20 workday period (75 subjects) and (c) visiting the HCCh for routine medical care. The Mini Mental State Examination (MMSE) was used in assessing the cognitive capacity of the participants. Blood was drawn for serum hematocrit, vitamin B12 and folate determination. The prevalence proportions of possible cognitive impairment among anemic and non-anemic males were 55.6% and 34.4%, respectively (X2 = 5.8, d.f. = 1, p = 0.016). The corresponding proportions in females were 47.5% and 40.1 % (X2 = 1.1, d.f. = 1, p = 0.305). Using logistic regression analysis, age-group (≥ 80 yrs), type of Institute, vitamin B12 and anemia had significant independent associations with possible cognitive impairment. Anemia is a frequent finding in elderly and it may be a risk factor for dementia, but the extent of the associated deterioration of cognitive impairment or the relation with AD is not known. GPs should be aware of this coexistence and recommend for screening, assaying and treating elderly people.