Novel olfactory ligands via terpene synthases
Novel olfactory ligands via terpene synthases
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DOI：
10.1039/c5cc01814e
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Allemann, Rudolf K.
中科院分区：
文献类型：
--
作者：
Touchet, Sabrina;Chamberlain, Keith;Allemann, Rudolf K.
一种通过提供非天然底物来合成嗅觉配体类似物的合成生物学方法被描述为一种可行的替代大部分不成功的配体对接研究的方法(S)--作为一种植物来源的驱虫剂的嗅觉配体D，以产生新的配体。(S)-14，15-二甲基吉马烯D表现出意想不到的行为活动逆转。
A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.