Magnetic resonance spectroscopic evidence for pre supplementary motor area neuronal dysfunction in Parkinson's disease
Magnetic resonance spectroscopic evidence for pre supplementary motor area neuronal dysfunction in Parkinson's disease
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DOI：
10.1002/mds.21288
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发表时间：
2007-02-15
影响因子：
8.6
通讯作者：
Martin, W. R. Wayne
中科院分区：
文献类型：
--
作者：
Camicioli, Richard M.;Hanstock, Christopher C.;Martin, W. R. Wayne
帕金森病（PD）患者的扣带回前部（AC）和前辅助运动区（pre-SMA）存在病理改变。我们检查了PD患者是否显示AC、SMA前或后扣带回（PC）中NAA/Cr的磁共振波谱（MRS）变化。44例（27例男性，17例女性）健康的非痴呆PD患者和38例（18例男性，20例女性）65岁及以上的对照组进行了检查，使用统一帕金森病评定量表（CAFRS），简易精神状态检查，额叶评估电池，老年抑郁量表。在1.5T下进行MRS。将体素（8 cc; PRESS; TE = 80; TR = 1，600 ms）置于矢状面中部。使用SPM 2测量体素内的灰质和白色物质体积。使用LC模型分析光谱以产生NAA/Cr和Cho/Cr。两组之间的人口统计学和认知测量没有差异。PD的运动功能评分为17.7 +/- 8.8。PD患者SMA前NAA/Cr较低（PD：1.39 +/- 0.17;对照：1.47 +/- 0.16; P = 0.045），与年龄呈负相关（r = 0.39; P = 0.01）。但不包括病程、疾病持续时间或多巴胺当量。AC和PC各部位NAA/Cr和Cho/Cr无显著性差异（P > 0.05）。总之，SMA前NAA/Cr在PD中选择性降低，与神经元功能障碍一致。这应该作为PD疾病的生物标志物进一步检查。(C)2007年，《社会运动》创刊。
The anterior cingulate (AC) gyrus and the presupplementary motor area (pre-SMA) show pathological changes in Parkinson's disease (PD). We examined if PD patients show magnetic resonance spectroscopy (MRS) changes in NAA/Cr in the AC, pre-SMA, or posterior cingulate (PC). Forty-four (27 male, 17 female) healthy nondemented PD patients and 38 controls (18 male, 20 female) 65 years of age and older were examined using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination, Frontal Assessment Battery, and Geriatric Depression Scale. MRS was performed at 1.5 T. Voxels (8 cc; PRESS; TE = 80; TR = 1,600 ms) were placed mid-sagittally. Gray matter and white matter volumes were measured within voxels using SPM2. Spectra were analyzed using LC model to yield NAA/Cr and Cho/Cr. Demographic and cognitive measures did not differ between groups. Motor UPDRS was 17.7 +/- 8.8 for PD. Pre-SMA NAA/Cr was lower in PD (PD: 1.39 +/- 0.17; control: 1.47 +/- 0.16; P = 0.045) and correlated negatively with age (r = 0.39; P = 0.01). but not with UPDRS, disease duration, or dopamine equivalents. AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD. (C) 2007 Movement Disorder Society.