Adverse Reaction in Patients with Drug Allergy History After Simultaneous Intravenous Fundus Fluorescein Angiography and Indocyanine Green Angiography
Adverse Reaction in Patients with Drug Allergy History After Simultaneous Intravenous Fundus Fluorescein Angiography and Indocyanine Green Angiography
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DOI：
10.1089/jop.2011.0221
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发表时间：
2012-08-01
影响因子：
2.3
通讯作者：
Shu, Xiaohong
中科院分区：
文献类型：
--
作者：
Su, Zhaoan;Ye, Panpan;Shu, Xiaohong
目的：探讨门诊同时进行静脉荧光素眼底血管造影（IVFA）和吲哚菁绿血管造影（ICGA）对任何/所有药物过敏史患者的安全性。方法：在2007年2月至2011年3月进行的单中心回顾性研究中，连续纳入390例有药物过敏史的门诊患者和3426例无过敏史的患者。 同时接受静脉 IVFA 和 ICGA。记录所有患者详细的药物过敏史、同时IVFA和ICGA期间出现不良反应的症状和时间。结果：在接受IVFA和ICGA的390例有药物过敏史的患者中，28例（7.2%）出现不良反应。相比之下，3426 名无过敏史的患者中有 145 名（4.2%）在同时 IVFA 和 ICGA 期间出现不良反应。有药物过敏史的患者与无药物过敏史的患者不良反应发生率（P = 0.008）和严重程度（P = 0.001）差异有统计学意义。在390例有药物过敏史的患者中，不同类型药物过敏的不良反应发生率差异无统计学意义（P>0.05）。结论：同时进行IFVA和ICGA总体上是安全的手术，不良反应发生率在可接受的范围内。然而，有药物过敏史的患者不良反应发生率可能更高且更严重。
Purpose: To examine the safety of outpatient clinic simultaneous intravenous fundus fluorescein angiography (IVFA) and indocyanine green angiography (ICGA) in patients with any/all drug allergy history.Methods: In a single-center retrospective study conducted from February 2007 to March 2011, 390 consecutive outpatients with drug allergy history and 3426 patients without allergy history underwent simultaneous intravenous IVFA and ICGA. The detailed drug allergy history, the symptoms and time of the adverse reaction during simultaneous IVFA and ICGA were recorded in all the patients.Results: Of the 390 patients with drug allergy history who received IVFA and ICGA, 28 patients (7.2%) had an adverse reaction. In contrast, 145 of the 3426 patients (4.2%) without allergy history had an adverse reaction during simultaneous IVFA and ICGA. Statistical significance in the incidence (P = 0.008) and severity (P = 0.001) of the adverse reaction was observed between patients with drug allergy history and those without drug allergy history. In 390 patients with drug allergy history, no statistical significance was indicated in the incidence of the adverse reaction among different types of drug allergy (P > 0.05).Conclusions: Simultaneous IFVA and ICGA are generally safe procedures with an acceptable incidence of an adverse reaction. However, patients with drug allergy history may have a higher incidence and greater severity of an adverse reaction.