Resveratrol inhibition of Propionibacterium acnes
Resveratrol inhibition of Propionibacterium acnes
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DOI：
10.1093/jac/dkm099
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发表时间：
2007-06-01
影响因子：
5.2
通讯作者：
Booth, Tristan D.
中科院分区：
文献类型：
--
作者：
Dochertyl, John J.;McEwen, Heather A.;Booth, Tristan D.
目的：为了评价抗炎羟基二苯乙烯（resveratrol）对痤疮丙酸杆菌生长的影响，方法：在0和200 mg/L之间的浓度下测试三种不同的痤疮丙酸杆菌菌株对白藜芦醇的作用。结果：白藜芦醇作用24 h后，对3株痤疮放线菌的平均50%抑制浓度（IC 50）为73 mg/L，平均100%抑制浓度（IC 100）为187 mg/L。白藜芦醇的IC 50和IC 100分别为123和234 mg/L。最高浓度的白藜芦醇测试（200 mg/L）是杀菌，而较低浓度是抑菌。结论：白藜芦醇，抗炎羟基芪，是能够抑制痤疮丙酸杆菌的生长。
Objectives: To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium, acnes growth.Methods: Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L. Piceatannol was included as a second hydroxystilbene to compare with resveratrol, and erythromycin and benzoyl peroxide were used as positive controls.Results: After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC50) was 73 mg/L and the average 100% inhibitory concentration (IC100) was 187 mg/L for the three strains of A acnes tested. The IC50 and IC100 of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic.Conclusions: Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.