Factors Associated with Age-Related Declines in Cardiorespiratory Fitness from Early Adulthood Through Midlife: CARDIA.
Factors Associated with Age-Related Declines in Cardiorespiratory Fitness from Early Adulthood Through Midlife: CARDIA.
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从成年早期到中年，与年龄相关的心肺健康下降相关的因素：CARDIA。
DOI：
10.1249/mss.0000000000002893
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发表时间：
2022-07-01
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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作者：
描述从成年早期到中年的最大和次最大心肺适应性，并通过社会人口统计学、行为和健康相关因素的子类别，检查20岁时最大适应性的差异和适应性随时间的变化。数据包括5，018名年轻成人参与者的冠状动脉风险发展[平均（SD）年龄24.8（3.7）岁，53.3%女性和51.4%黑人参与者]，他们在基线和/或7年和20年检查时完成了至少一项最大分级运动试验。在第2阶段结束时，通过运动持续时间和心率估计最大和次最大适应性。多变量调整线性混合模型用于估计健身轨迹，使用年龄作为协变量调整后的时间机制。从20岁到50岁的健身轨迹在5年的增量估计整体和亚组确定的每个因素调整后的持续时间内不太有利的类别。20岁和50岁时的平均（95%置信区间）最大健康为613（607，616）和357（350，362）秒;在此期间的次最大心率也反映了与年龄相关的健康下降[每分钟126（125，127）和138（137，138）次]。与男性相比，女性在20岁时的最大适应性较低（p<0.001），并在随访期间持续存在（p<0.001）;性别分层内的种族也存在差异（均p<0.001）。20岁时最大适应性的差异在青年期的社会经济、行为和健康相关状态中被注意到（所有p<0.05），这些差异在随访期间持续存在（所有p<0.001），并且在性别分层分析中基本一致。针对个体经历加速健身下降与定制的干预策略可能提供一个机会，以保持整个中年健身，以减少终身心血管疾病的风险。
To describe maximal and submaximal cardiorespiratory fitness from early adulthood to midlife and examine differences in maximal fitness at age 20 and changes in fitness over-time by sub-categories of socio-demographic, behavioral, and health-related factors. Data include 5,018 Coronary Artery Risk Development in Young Adults participants [mean (SD) age 24.8 (3.7) years, 53.3% female and 51.4% Black participants] who completed at least one maximal graded exercise test at baseline and/or the Year 7 and 20 exams. Maximal and submaximal fitness were estimated by exercise duration and heart rate at the end of stage 2. Multivariable adjusted linear mixed models were used to estimate fitness trajectories using age as the mechanism for time after adjustment for covariates. Fitness trajectories from ages 20 to 50 in 5-year increments were estimated overall and by sub-groups determined by each factor after adjustment for duration within the less favorable category. Mean (95% confidence interval) maximal fitness at age 20 and 50 years was 613 (607, 616) and 357 (350, 362) seconds; submaximal heart rate during this period also reflected age-related fitness declines [126 (125, 127) and 138 (137, 138) beats per minute]. Compared to men, women had lower maximal fitness at age 20 (p<0.001), which persisted over follow-up (p<0.001); differences were also found by race within sex-strata (all p<0.001). Differences in maximal fitness at age 20 were noted by socio-economic, behavioral, and health-related status in young adulthood (all p<0.05), which persisted over follow-up (all p<0.001) and were generally consistent in sex-stratified analyses. Targeting individuals experiencing accelerated fitness declines with tailored intervention strategies may provide an opportunity to preserve fitness throughout midlife to reduce lifetime cardiovascular disease risk.
影响因子：
5.1
作者：
Pettee Gabriel K;Whitaker KM;Duprez D;Sternfeld B;Lewis CE;Sidney S;Knell G;Jacobs DR Jr
通讯作者：
Jacobs DR Jr