Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort.
Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort.
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DOI：
10.3945/ajcn.115.111989
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Travis RC
中科院分区：
文献类型：
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作者：
Schmidt JA;Rinaldi S;Ferrari P;Carayol M;Achaintre D;Scalbert A;Cross AJ;Gunter MJ;Fensom GK;Appleby PN;Key TJ;Travis RC
背景资料：人体代谢受饮食因素和生活方式，环境和遗传因素的影响;因此，从饮食中排除部分或全部动物产品的男性可能具有与肉食者不同的代谢特征。目的：我们的目的是调查118个循环代谢物的浓度差异，包括酰基肉毒碱，氨基酸，生物胺，甘油磷脂，己糖和鞘脂相关的脂质，蛋白质和碳水化合物代谢之间的男性肉食者，鱼食者，素食者和纯素食者从牛津手臂的欧洲癌症和营养的前瞻性调查。设计图：在这项横断面研究中，通过质谱法测量了379名根据饮食组分类的男性血浆中代谢物的浓度。通过使用ANOVA测试饮食组间平均代谢物浓度的差异，并使用错误发现率控制程序来解释多重测试。主成分分析用于研究代谢谱的模式。结果：79%的代谢物浓度在不同饮食组之间存在显著差异。在绝大多数情况下，素食者的浓度最低，而肉食者的酰基肉毒碱、甘油磷脂和鞘脂的浓度最高，而食鱼者或素食者的氨基酸和生物胺的浓度最高。观察到4个饮食组的代谢模式之间存在明显的分离，纯素食者与其他组明显不同，因为一些甘油磷脂和鞘脂的浓度较低。结论：血浆中的代谢谱可以有效地区分来自不同习惯饮食组的男性，特别是素食男性与食用动物产品的男性。代谢谱的差异主要是由纯素食者中甘油磷脂和鞘脂的浓度较低来解释的。
Background: Human metabolism is influenced by dietary factors and lifestyle, environmental, and genetic factors; thus, men who exclude some or all animal products from their diet might have different metabolic profiles than meat eaters. Objective: We aimed to investigate differences in concentrations of 118 circulating metabolites, including acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose, and sphingolipids related to lipid, protein, and carbohydrate metabolism between male meat eaters, fish eaters, vegetarians, and vegans from the Oxford arm of the European Prospective Investigation into Cancer and Nutrition. Design: In this cross-sectional study, concentrations of metabolites were measured by mass spectrometry in plasma from 379 men categorized according to their diet group. Differences in mean metabolite concentrations across diet groups were tested by using ANOVA, and a false discovery rate–controlling procedure was used to account for multiple testing. Principal component analysis was used to investigate patterns in metabolic profiles. Results: Concentrations of 79% of metabolites differed significantly by diet group. In the vast majority of these cases, vegans had the lowest concentration, whereas meat eaters most often had the highest concentrations of the acylcarnitines, glycerophospholipids, and sphingolipids, and fish eaters or vegetarians most often had the highest concentrations of the amino acids and a biogenic amine. A clear separation between patterns in the metabolic profiles of the 4 diet groups was seen, with vegans being noticeably different from the other groups because of lower concentrations of some glycerophospholipids and sphingolipids. Conclusions: Metabolic profiles in plasma could effectively differentiate between men from different habitual diet groups, especially vegan men compared with men who consume animal products. The difference in metabolic profiles was mainly explained by the lower concentrations of glycerophospholipids and sphingolipids in vegans.