Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy.
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy.
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DOI：
10.1158/1078-0432.ccr-12-0205
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发表时间：
2012-06-01
期刊：
影响因子：
--
通讯作者：
Dougherty PM
中科院分区：
文献类型：
--
作者：
Boyette-Davis JA;Eng C;Wang XS;Cleeland CS;Wendelschafer-Crabb G;Kennedy WR;Simone DA;Zhang H;Dougherty PM
Of the numerous complications associated with cancer and cancer treatment, peripheral neuropathy is a deleterious and persistent patient complaint commonly attributed to chemotherapy. The present study investigated the occurrence of subclinical peripheral neuropathy in patients with colorectal cancer prior to the initiation of chemotherapy. Fifty-two (52) patients underwent extensive quantitative sensory testing (QST) prior to receiving chemotherapy. Changes in multiple functions of primary afferent fibers were assessed and compared to a group of healthy control subjects. Skin temperature, sensorimotor function, sharpness detection, and thermal detection were measured, as was touch detection, using both conventional (von Frey monofilaments) and novel (Bumps detection test) methodology. Patients had subclinical deficits, especially in sensorimotor function, detection of thermal stimuli, and touch detection that were present prior to the initiation of chemotherapy. The measured impairment in touch sensation was especially pronounced when using the Bumps detection test. The colorectal cancer patients in this study exhibited deficits in sensory function prior to undergoing chemotherapy treatment, implicating the disease itself as a contributing factor in chemotherapy induced peripheral neuropathy. The widespread nature of the observed deficits further indicated that cancer is affecting multiple primary afferent subtypes. Specific to the finding of impaired touch sensation, results from this study highlight the use of newly employed methodology, the Bumps detection test, as a sensitive and useful tool in the early detection of peripheral neuropathy.
