DOUBLE-WALLED POLYMER MICROSPHERES FOR CONTROLLED DRUG-RELEASE
DOUBLE-WALLED POLYMER MICROSPHERES FOR CONTROLLED DRUG-RELEASE
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DOI：
10.1038/367258a0
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发表时间：
1994-01-20
期刊：
影响因子：
64.8
通讯作者：
MATHIOWITZ, E
中科院分区：
文献类型：
--
作者：
PEKAREK, KJ;JACOB, JS;MATHIOWITZ, E
控制药物释放的一种方法涉及将药物分子掺入微观聚合物球体或胶囊的基质中1 -10。然而，用于制备这种微粒的现有方法并不总是保证恒定的释放速率，例如因为药物分子可能优先被捕获在表面，因为当颗粒不侵蚀时它们必须扩散通过增加厚度的聚合物，或者因为表面积因侵蚀颗粒而改变。在其他情况下，可能需要脉冲释放-简单的聚合物微球不容易适用于这种应用。多壁微球可以解决其中的一些问题。在这里，我们描述了一个一步法制备双壁聚合物微球的直径范围从约20至1,000微米。我们的技术11涉及由于溶剂蒸发而导致的聚合物混合物的相分离：通过适当选择界面张力和蒸发速率，一种聚合物的球形液滴被另一种聚合物的高度均匀的层所包覆。这一过程，这可能是适应生产多壁微球，应使可能的工程高度特定的药物释放特性。
ONE approach to the controlled release of drugs involves incorporation of the drug molecules into the matrix of microscopic polymer spheres or capsules1-10. Existing methods for preparing such microparticles do not, however, always guarantee a constant release rate, for example because drug molecules may be trapped preferentially at the surface, because they have to diffuse through an increasing thickness of polymer when the particles are non-eroding or because the surface area changes for eroding particles. In other situations pulsed release may be required-an application to which simple polymer microspheres do not readily lend themselves. Multi-walled microspheres might solve some of these problems. Here we describe a one-step process for preparing double-walled polymer microspheres with diameters ranging from about 20 to 1,000 micrometres. Our technique11 involves the phase separation of a polymer mixture owing to solvent evaporation: with an appropriate choice of interfacial tensions and evaporation rate, a spherical droplet of one polymer becomes coated with a highly uniform layer of the other. This process, which might be adapted to yield multi-walled microspheres, should make possible the engineering of highly specific drug-release properties.