Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article
Preoperative thrombin generation is predictive for the risk of blood loss after cardiac surgery: a research article
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DOI：
10.1186/1749-8090-8-154
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发表时间：
2013-06-12
影响因子：
1.6
通讯作者：
Mochtar, Baheramsjah
中科院分区：
文献类型：
--
作者：
Bosch, Yvonne;Al Dieri, Raed;Mochtar, Baheramsjah
背景：在这项研究中，利用校准的自动血栓图测量的凝血酶生成参数对预测体外循环心脏手术后失血量的价值进行了研究。分别于肝素化前(T1)和鱼精蛋白注射后5分钟(T2)采血。凝血酶的生成在富含血小板的血浆和缺乏血小板的血浆中都被测量。除测定凝血酶生成外，还测定活化凝血时间、红细胞压积、血红蛋白、血小板数、纤维蛋白原、抗凝血酶、D-二聚体、凝血酶原时间和活化部分凝血活酶时间。术后测量失血量，记录输血量，直至术后20小时。根据术中出血量将患者分为两组(第1组：中位出血量=930ml)。结果：术后第1天，第2组患者的内源性凝血酶活性和峰值凝血酶活性明显降低(P
Background: In this study the value of thrombin generation parameters measured by the Calibrated Automated Thrombography for prediction of blood loss after cardiac surgery with cardiopulmonary bypass was investigated.Methods: Thirty male patients undergoing first-time coronary artery bypass grafting were enrolled. Blood samples were taken pre-bypass before heparinisation (T1) and 5 min after protamine administration (T2). Thrombin generation was measured both in platelet-rich plasma and in platelet-poor plasma. Besides thrombin generation measurements, activated clotting time, haematocrit, haemoglobin, platelet number, fibrinogen, antithrombin, D-dimers, prothrombin time and activated partial thromboplastin time were determined. Blood loss was measured and the amount of transfusion products was recorded postoperatively until 20 hours after surgery. Patients were divided into two groups based on the median volume of postoperative blood loss (group 1: patients with median blood loss = 930 ml).Results: On T1, patients of group 2 had a significantly lower endogenous thrombin potential and peak thrombin (p