SPINAL-CORD MORPHOLOGY AND PATHOLOGY IN OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT
SPINAL-CORD MORPHOLOGY AND PATHOLOGY IN OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT
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DOI：
10.1093/brain/118.1.263
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发表时间：
1995-02-01
期刊：
影响因子：
14.5
通讯作者：
MIZUNO, J
中科院分区：
文献类型：
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作者：
KAMEYAMA, T;HASHIZUME, Y;MIZUNO, J
我们分析了9例后纵韧带骨化(OPLL)的尸检病例，以阐明脊髓的形态与病理的关系。脊髓受影响最严重节段的横断面形态可分为两类：回旋型(凸侧表面和凹前表面)和三角形(角侧表面和平前表面)。在回旋镖形状的病例中，即使在受压严重的情况下，主要病变仅限于灰质，白质相对保存良好。侧柱未见二次向下退变，后柱向上退变仅限于楔束，其纤维来源于病变节段。三角型病变较重，白质和灰质均受累，仅前柱无病变。多节段病变严重，既有锥体外侧束的下行变性，也有包括股薄束在内的后柱的上行变性。在大多数回旋镖形状的病例中，脊髓的横截面积是正常的60%，但它被缩小到
We analysed nine autopsy cases of ossification of the posterior longitudinal ligament (OPLL) to elucidate the relationship between morphology and pathology of the spinal cord. The cross-sectional shape of the spinal cord at the most severely affected segment was classified into two categories: boomerang (convex lateral surfaces and concave anterior surface) and triangular (angular lateral surfaces and flat anterior surface). In the cases with a boomerang shape, even when the compression was severe, major pathological changes were restricted to the grey matter and the white matter was relatively well preserved. No secondary descending degeneration of the lateral columns was seen, and ascending degeneration of the posterior column was restricted to the fasciculus cuneatus whose fibres were derived from the affected segments. In the cases with a triangular shape, pathological changes were more severe, both white matter and grey matter were involved and only the anterior columns were free of pathological changes. There were severe pathological changes over more than one segment, and both descending degeneration of the lateral pyramidal tracts and ascending degeneration of the posterior column, including the fasciculus gracilis, were observed. The transverse area of the spinal cord was >60% of normal in most of the cases with a boomerang shape, but it was reduced to