Mechanochemical Asymmetric Transfer Hydrogenation of Diketones to Access Chiral 1,3-Diols under Solvent-Free Conditions
Mechanochemical Asymmetric Transfer Hydrogenation of Diketones to Access Chiral 1,3-Diols under Solvent-Free Conditions
复制标题
无溶剂条件下二酮的机械化学不对称转移氢化得到手性 1,3-二醇
作者：
Chengyi Wang;Shaomin Deng;Rui Chen;Guohua Liu;Tanyu Cheng;Rui Liu
摘要 开发了在无溶剂条件下钌络合物存在下二酮的机械化学不对称转移氢化（ATH），以提供手性 1,3-二醇衍生物。该方案受益于快速反应动力学、不使用溶剂和优异的对映选择性。此外，机械化学ATH反应可以很容易地在克级进行。
Abstract A mechanochemical asymmetric transfer hydrogenation (ATH) of diketones in the presence of a ruthenium complex under solvent-free conditions was developed to provide chiral 1,3-diol derivatives. This protocol benefits from rapid reaction kinetics, no use of solvents, and excellent enantioselectivity. In addition, the mechanochemical ATH reaction can easily be performed on a gram scale.