Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability
Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability
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DOI：
10.1183/09031936.03.00402403
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发表时间：
2003-05-01
影响因子：
24.3
通讯作者：
Cascio, W
中科院分区：
文献类型：
--
作者：
Devlin, RB;Ghio, AJ;Cascio, W
据认为，全球每年有50万人死于空气污染颗粒。风险最大的人群似乎是患有呼吸系统和心血管疾病的老年人。到目前为止，还没有提出普遍接受的机制来解释这些死亡的原因。研究人员对60至80岁的健康老年人进行了心率变异性（HRV）评估，这些老年人连续暴露两次，每次2小时：一次暴露在清洁空气中，一次暴露在集中的环境空气污染颗粒（CAPS）中。在暴露前、暴露后和暴露后24小时分别测量HRV的变化。老年受试者暴露后，HRV在时间和频率域均显著下降。其中一些变化持续了至少24小时。这些数据与先前研究中暴露于CAPS的年轻健康志愿者的HRV数据进行了比较，在先前的研究中，没有发现CAPS引起的HRV变化。在一项对照人体暴露研究中，这些高浓度环境空气污染颗粒引起的心率变异性变化扩展了最近小组研究报告的类似发现，并提出了颗粒物质可能诱发不良心血管事件的潜在机制。
Air pollution particles are thought to kill 500,000 people worldwide each year. The population most at risk appears to be elderly people with respiratory and cardiovascular disease. As yet, no commonly accepted mechanism has been proposed which can explain the cause of these deaths.'Heart rate variability (HRV) was assessed in healthy elderly adults between the ages of 60 and 80 who were exposed twice for 2 h: once to clean air and once to concentrated ambient air pollution particles (CAPS). Changes in HRV were measured immediately before, immediately following, and 24 h after exposure.Elderly subjects experienced significant decreases in HRV in both time and frequency domains immediately following exposure. Some of these changes persisted for at least 24 h. These data were compared with HRV data collected from young healthy volunteers exposed to CAPS in a previous study, in which no CAPS-induced changes in HRV were found.These concentrated ambient air pollution particle-induced changes in heart rate variability in a controlled human exposure study extend similar findings reported in recent panel studies and suggest potential mechanisms by which particulate matter may induce adverse cardiovascular events.