Treadmill measures of ambulation rates in ovine models of spinal cord injury and neuropathic pain
Treadmill measures of ambulation rates in ovine models of spinal cord injury and neuropathic pain
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DOI：
10.3109/03091902.2015.1132786
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发表时间：
2016-04-02
影响因子：
--
通讯作者：
Howard, M. A., III
中科院分区：
文献类型：
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作者：
Safayi, S.;Miller, J. W.;Howard, M. A., III
我们的实验室正在开发基于跑步机的步态分析，利用绵羊来研究硬膜内脊髓刺激在治疗脊髓损伤和神经性疼痛中的潜在功效。作为建立实验安排的性能特征的一部分，本研究通过转速计、视频带标记计时和绵羊的行走率观察来测量跑步机的速度。数据显示基线（空载）跑步机速度有 0.1-0.3% 的残余漂移，该漂移随着负载的增加而增加，但所有三种方法都同意最终速度在 1.7% 以内，皮带速度约为 4 km/h。使用转速计作为标准，视频带标记方法中不确定性的估计上限为+/- 0.18 km h(-1)，测量的不确定性为+/- 0.15 km h(-1)。使用后一种方法来确定羊对侧蹄撞击之间的时间差异表明其在评估 SCI 严重程度和对治疗干预的反应方面的实用性。
Our laboratories are developing treadmill-based gait analysis employing sheep to investigate potential efficacy of intra-dural spinal cord stimulation in the treatment of spinal cord injury and neuropathic pain. As part of efforts to establish the performance characteristics of the experimental arrangement, this study measured the treadmill speed via a tachometer, video belt-marker timing and ambulation-rate observations of the sheep. The data reveal a 0.1-0.3% residual drift in the baseline (unloaded) treadmill speed which increases with loading, but all three approaches agree on final speed to within 1.7%, at belt speeds of approximate to 4 km/h. Using the tachometer as the standard, the estimated upper limit on uncertainty in the video belt-marker approach is +/- 0.18 km h(-1) and the measured uncertainty is +/- 0.15 km h(-1). Employment of the latter method in determining timing differences between contralateral hoof strikes by the sheep suggests its utility in assessing severity of SCI and responses to therapeutic interventions.