Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas
Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas
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DOI：
10.14219/jada.archive.2010.0223
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发表时间：
2010-05-01
影响因子：
3.9
通讯作者：
Meyer, Daniel M.
中科院分区：
文献类型：
--
作者：
Rethman, Michael P.;Carpenter, William;Meyer, Daniel M.
背景本文介绍了由美国牙科协会科学事务理事会召集的专家组制定的循证临床建议。本报告讨论了口腔鳞状细胞癌筛查的潜在益处和潜在风险，以及使用连续性筛查辅助工具来可视化和检测潜在的恶性和恶性口腔病变。专家组成员对MEDLINE进行了系统检索，确定了332篇系统综述和1，499项近期临床研究。他们选择了五个系统评价和四个临床研究作为发展的基础。专家组的结论是，通过视觉和触觉检查来检测潜在的恶性和恶性病变的筛查可能会导致在发展的早期阶段发现口腔癌，但没有足够的证据来确定筛查是否会改变寻求牙科护理的无症状人群的疾病特异性死亡率。专家组建议临床医生在对所有患者进行常规视觉和触觉检查时，对潜在恶性病变或早期癌症的迹象保持警惕，特别是那些吸烟或大量饮酒的患者。需要对口腔癌筛查和抗肿瘤药物的使用进行更多的研究。
Background. This article presents evidence-based clinical recommendations developed by a panel convened by the American Dental Association Council on Scientific Affairs. This report addresses the potential benefits and potential risks of screening for oral squamous cell carcinomas and the use of adjunctive screening aids to visualize and detect potentially malignant and malignant oral lesions.Types of Studies Reviewed. The panel members conducted a systematic search of MEDLINE, identifying 332 systematic reviews and 1,499 recent clinical studies. They selected five systematic reviews and four clinical studies to use as a basis for developing recommendations.Results. The panel concluded that screening by means of visual and tactile examination to detect potentially malignant and malignant lesions may result in detection of oral cancers at early stages of development, but that there is insufficient evidence to determine if screening alters disease-specific mortality in asymptomatic people seeking dental care.Clinical Implications. The panel suggested that clinicians remain alert for signs of potentially malignant lesions or early-stage cancers while performing routine visual and tactile examinations in all patients, but particularly in those who use tobacco or who consume alcohol heavily. Additional research regarding oral cancer screening and the use of adjuncts is needed.