Two new humulanolides from the roots of Cynanchum wilfordii
Two new humulanolides from the roots of Cynanchum wilfordii
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两种来自徐长卿根的新葎草醇内酯
DOI：
10.1016/j.tetlet.2015.10.016
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发表时间：
2015-11-18
影响因子：
1.8
通讯作者：
Zhao, Wei-Min
中科院分区：
文献类型：
--
作者：
Li, Jin-Long;Fu, Yan;Zhao, Wei-Min
从白首乌根中分离得到两个稀有的虎杖内酯A(1)和B(2)，它们具有一个不寻常的双环[6.3.0]十一烷核和邻接的丁内酯部分。它们的结构通过光谱分析得到确证，绝对构型通过X射线衍射法得到确证。这是夹竹桃科虎杖内酯的第一个字母。化合物1具有较弱的乙酰胆碱酯酶抑制活性。(C)2015爱思唯尔有限公司。保留所有权利。
Wilfolides A (1) and B (2), two rare humulanolides with an unusual bicyclo[6.3.0]undecane core and an adjoining butyrolactone moiety, were isolated from the roots of Cynanchum wilfordii. Their structures were elucidated by spectroscopic analysis, and the absolute configurations were confirmed by X-ray crystallography using Cu K alpha radiation. This is the first Letter of humulanolides from the family Apocynaceae. Compound 1 exhibited weak acetylcholinesterase inhibitory activity. (C) 2015 Elsevier Ltd. All rights reserved.