Stem cell therapy for chronic obstructive pulmonary disease.
Stem cell therapy for chronic obstructive pulmonary disease.
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DOI：
10.1097/cm9.0000000000001596
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发表时间：
2021-06-15
影响因子：
6.1
通讯作者：
Xiong WN
中科院分区：
文献类型：
--
作者：
Chen YT;Miao K;Zhou L;Xiong WN
慢性阻塞性肺疾病(COPD)是目前世界上分布最广泛的慢性肺病之一，以持续性且不完全可逆的气流受限为特征。慢性阻塞性肺疾病最常见的症状是咳嗽、咳痰和用力呼吸困难。尽管在过去的几十年里已经制定了各种治疗策略，但目前对COPD的医学治疗仅侧重于症状的缓解，而扭转肺功能恶化和改善患者生活质量的作用非常有限。因此，迫切需要开发新的有效的COPD治疗策略。已知干细胞可以分化为各种类型的细胞，并用于再生肺实质和呼吸道结构。干细胞治疗是一种很有前途的治疗策略，有可能恢复COPD患者的肺功能，提高患者的生活质量。本文综述了间充质干细胞治疗慢性阻塞性肺疾病的临床研究现状，旨在提高对间充质干细胞在慢性阻塞性肺疾病治疗中作用的认识，以期为临床制定有效的治疗策略提供参考。
Chronic obstructive pulmonary disease (COPD), characterized by persistent and not fully reversible airflow restrictions, is currently one of the most widespread chronic lung diseases in the world. The most common symptoms of COPD are cough, expectoration, and exertional dyspnea. Although various strategies have been developed during the last few decades, current medical treatment for COPD only focuses on the relief of symptoms, and the reversal of lung function deterioration and improvement in patient's quality of life are very limited. Consequently, development of novel effective therapeutic strategies for COPD is urgently needed. Stem cells were known to differentiate into a variety of cell types and used to regenerate lung parenchyma and airway structures. Stem cell therapy is a promising therapeutic strategy that has the potential to restore the lung function and improve the quality of life in patients with COPD. This review summarizes the current state of knowledge regarding the clinical research on the treatment of COPD with mesenchymal stem cells (MSCs) and aims to update the understanding of the role of MSCs in COPD treatment, which may be helpful for developing effective therapeutic strategies in clinical settings.
DOI：
10.1186/1476-9255-9-27
发表时间：
2012-07-02
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Antoniou KM;Margaritopoulos GA;Proklou A;Karagiannis K;Lasithiotaki I;Soufla G;Kastrinaki MC;Spandidos DA;Papadaki HA;Siafakas NM
通讯作者：
Siafakas NM