Dizziness and the genetic influences on subjective experiences to initial cigarette use
Dizziness and the genetic influences on subjective experiences to initial cigarette use
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DOI：
10.1111/j.1360-0443.2010.03133.x
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发表时间：
2011-02-01
期刊：
影响因子：
6
通讯作者：
Hewitt, John K.
中科院分区：
文献类型：
--
作者：
Haberstick, Brett C.;Ehringer, Marissa A.;Hewitt, John K.
目的探讨个体对初次吸烟的积极和消极主观体验的差异。设计回顾性自我报告的初次主观体验进行了检查，以估计遗传和环境的影响，以及它们在不同影响之间的协变程度。数据来自2482名年轻的成年同性和异性双胞胎。采用早期吸烟经验（ESE）回顾性收集了参与国家青少年健康纵向研究的儿童和兄弟姐妹的主观经验调查问卷。结果积极的经验证明中度遗传的贡献（40%，95% CI：0.22至0.56），总体享乐指标（34%，95% CI：0.22至0.46）和头晕（34%，95% CI：0.15至0.52）也是如此。负面经历证明了小的遗传贡献（13%，95% CI：0.00至0.36）。个别特定的环境影响是强大的，并占其余比例的观察到的变化，在这些经验。多变量遗传模型确定了一个中度遗传的潜在因素（37%，95%CI：0.22至0.52），影响不同的主观经验的协变，并加载最严重的头晕。积极的经验也证据残留的遗传影响，与其他主观experiences.ConclusionsHow一个人的经验，他们最初的几支香烟是由于遗传的贡献和环境的经验，独特的人。不同主观体验的共变似乎是由于对普通香烟中所含化学物质的遗传性潜在敏感性，并且最好通过头晕来索引。
AimTo examine individual differences in positive and negative subjective experiences to initial cigarette use.DesignRetrospective self-reports of initial subjective experiences were examined to estimate the genetic and environmental influences and the extent of their covariation across different effects.ParticipantsData was drawn from 2482 young adult same-and opposite sex twins- and siblings participating in the National Longitudinal Study of Adolescent Health.MeasurementSubjective experiences were retrospectively collected using the Early Smoking Experience (ESE) questionnaire.FindingsPositive experiences evidenced moderate heritable contributions (40%, 95% CI: 0.22 to 0.56), as did an overall hedonic measure (34%, 95% CI: 0.22 to 0.46) and dizziness (34%, 95% CI: 0.15 to 0.52). Negative experiences evidenced small heritable contributions (13%, 95% CI: 0.00 to 0.36). Individual specific environmental influences were strong and accounted for the remaining proportion of observed variation in these experiences. Multivariate genetic modeling identified a moderately heritable underlying factor (37%, 95% CI: 0.22 to 0.52) that influenced the covariation of diverse subjective experiences and loaded most heavily on dizziness. Positive experiences also evidence residual genetic influences that were uncorrelated with other subjective experiences.ConclusionsHow a person experiences their initial few cigarettes is due to both heritable contributions and environmental experiences unique to the person. The covariation of diverse subjective experiences appears to be due to a heritable latent sensitivity to the chemicals contained in an average cigarette and is best indexed by dizziness.