The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology
The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology
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DOI：
10.1080/02656736.2020.1746413
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发表时间：
2020-07-15
影响因子：
3.1
通讯作者：
Fecci, Peter E.
中科院分区：
文献类型：
--
作者：
Srinivasan, Ethan S.;Sankey, Eric W.;Fecci, Peter E.
免疫疗法（IT）在肿瘤治疗中的兴起极大地改善了许多疾病状态的结果。然而，由于与独特的免疫肿瘤微环境相关的多种原因，其在中枢神经系统（CNS）肿瘤中的应用仍然有限。因此，考虑IT与其他治疗方法的交叉是有价值的，这些治疗方法可以改善CNS的可及性和现有IT模式的有效性。一种这样的组合是IT与通过诸如激光间质热疗法（LITT）的技术产生的局部热疗（HT）的配对。局部和全身HT的广泛免疫调节作用已经研究了一段时间。热疗已经在肿瘤细胞、免疫细胞和控制潜在免疫监视的更广泛环境的水平上证明了免疫刺激作用。深入了解这些影响，以及目前和即将进行的调查，这样结合IT是重要的，在考虑未来的方向神经肿瘤学。
The rise of immunotherapy (IT) in oncological treatment has greatly improved outcomes in a number of disease states. However, its use in tumors of the central nervous system (CNS) remains limited for multiple reasons related to the unique immunologic tumor microenvironment. As such, it is valuable to consider the intersection of IT with additional treatment methods that may improve access to the CNS and effectiveness of existing IT modalities. One such combination is the pairing of IT with localized hyperthermia (HT) generated through technologies such as laser interstitial thermal therapy (LITT). The wide-ranging immunomodulatory effects of localized and whole-body HT have been investigated for some time. Hyperthermia has demonstrated immunostimulatory effects at the level of tumor cells, immune cells, and the broader environment governing potential immune surveillance. A thorough understanding of these effects as well as the current and upcoming investigations of such in combination with IT is important in considering the future directions of neuro-oncology.