Evolutionary relationships among virulence-associated histidine kinases
Evolutionary relationships among virulence-associated histidine kinases
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DOI：
10.1128/iai.69.8.5207-5211.2001
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发表时间：
2001-08-01
影响因子：
3.1
通讯作者：
Hancock, REW
中科院分区：
文献类型：
--
作者：
Brinkman, FSL;MacFarlane, ELA;Hancock, REW
观察到真菌和天蓝色链霉菌的毒力相关组氨酸激酶之间有很强的相关性，系统发育分析表明这些生物的祖先之间发生了细菌到真核生物的水平基因转移。系统发育分析还鉴定了一组与链霉菌蛋白同源的组氨酸激酶，其中包括铜绿假单胞菌Gacs。我们提供的证据表明，Gacs对于小鼠的集群运动、脂肪酶的产生和毒力是重要的，并且已经进化成与PhoQ有部分功能重叠，PhoQ是一种与毒力相关的组氨酸激酶。
A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms. Phylogenetic analysis also identified a group of histidine kinases orthologous to the Streptomyces proteins that includes Pseudomonas aeruginosa GacS. We provide evidence that GacS is important for swarming motility, lipase production, and virulence in mice and had evolved to have partial functional overlaps with PhoQ, a less-related virulence-associated histidine kinase.