Building Scaffolds for Tubular Tissue Engineering.
Building Scaffolds for Tubular Tissue Engineering.
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DOI：
10.3389/fbioe.2020.589960
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发表时间：
2020
影响因子：
5.7
通讯作者：
Owens RM
中科院分区：
文献类型：
--
作者：
Boys AJ;Barron SL;Tilev D;Owens RM
中空器官和组织系统驱动身体的各种功能。许多这些中空或管状系统，如脉管系统、肠和气管，是组织工程的常见目标，因为它们与许多疾病和身体功能相关。随着组织工程领域的发展，已经产生了许多台式模型作为基础科学和药物测试的平台。用于不同组织工程应用的管状支架的生产具有许多共性，例如需要生产完整的管状开口和形成半渗透性上皮细胞或内皮细胞。因此，该领域已经集中在用于生产这些结构的一系列制造技术上。在这篇综述中，我们讨论了一些最常见的组织工程应用的背景下，管状组织和这些结构可以产生的方法。我们提供了一个概述的一般结构和解剖结构，这些组织系统沿着与一系列的一般设计标准的管状组织工程。我们将制造管状支架的方法分类如下：铸造，静电纺丝，轧制，3D打印和脱细胞化。我们讨论了血管，肠道和气管组织工程的背景下，最先进的模型。最后，我们总结了这些领域的未来的讨论。
Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engineering has developed, numerous benchtop models have been produced as platforms for basic science and drug testing. Production of tubular scaffolds for different tissue engineering applications possesses many commonalities, such as the necessity for producing an intact tubular opening and for formation of semi-permeable epithelia or endothelia. As such, the field has converged on a series of manufacturing techniques for producing these structures. In this review, we discuss some of the most common tissue engineered applications within the context of tubular tissues and the methods by which these structures can be produced. We provide an overview of the general structure and anatomy for these tissue systems along with a series of general design criteria for tubular tissue engineering. We categorize methods for manufacturing tubular scaffolds as follows: casting, electrospinning, rolling, 3D printing, and decellularization. We discuss state-of-the-art models within the context of vascular, intestinal, and tracheal tissue engineering. Finally, we conclude with a discussion of the future for these fields.