Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART
Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART
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DOI：
10.1097/qad.0b013e328339cf40
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发表时间：
2010-06-19
期刊：
影响因子：
3.8
通讯作者：
Monforte, Antonella d'Arminio
中科院分区：
文献类型：
--
作者：
Marchetti, Giulia;Gazzola, Lidia;Monforte, Antonella d'Arminio
目的：分析低CD4(+) hiv感染患者在进行病毒抑制性HAART治疗时功能定义的t细胞分化，对于设计临床有效的治疗方案至关重要。方法：我们横切面研究了34例hiv感染的免疫无应答（INRs）中CD4（+）和CD8(+) T细胞的成熟（CD45RA/CCR7, CD7）和功能[抗原特异性酶联免疫吸附斑点试验（ELISPOT），白细胞介素-2 (IL-2)/干扰素- γ产生细胞]:CD4（+）细胞计数小于或等于200个细胞/ μ l， HIV-RNA 50拷贝/ml或更少，与20例完全应答(CD4(+) bb0 500个细胞/ μ l， HIV-RNA
Objective: Analysis of functionally defined T-cell differentiation in HIV-infected patients with low CD4(+) on virologically suppressive HAART is crucial to design clinically efficacious treatments.Methods: We cross-sectionally investigated the maturation (CD45RA/CCR7, CD7) and function [antigen-specific enzyme-linked immunosorbent spot assay (ELISPOT), interleukin-2 (IL-2)/interferon-gamma-producing cells] of CD4(+) and CD8(+) T cells in 34 HIV-infected immunological nonresponders (INRs): CD4(+) cell count less than or equal to 200 cells/mu l, HIV-RNA 50 copies/ml or less, as compared to 20 full responders (CD4(+) >500 cells/mu l, HIV-RNA