Prenatal cocaine exposure: An examination of childhood externalizing and internalizing behavior problems at age 7 years
Prenatal cocaine exposure: An examination of childhood externalizing and internalizing behavior problems at age 7 years
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DOI：
10.1017/s1121189x00002001
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Bandstra, ES
中科院分区：
文献类型：
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作者：
Accornero, VH;Anthony, JC;Bandstra, ES
目的：本研究探讨了产前可卡因暴露与父母报告的7岁儿童行为问题之间的关系。方法-数据来自407名非洲裔美国儿童（210名可卡因暴露，197名非可卡因暴露），这些儿童在出生时前瞻性地参加了一项关于子宫内暴露于可卡因的神经发育后果的纵向研究。通过母亲自我报告和生物测定（母亲和婴儿尿液和婴儿胎粪），在分娩时评估产前可卡因暴露。Achenbach儿童行为检查表（CBCL）是一项衡量儿童期外化和内化行为问题的指标，由儿童目前的主要照顾者在儿童7岁时安排的评估访问期间完成。结果-结构方程和GLM/GEE模型显示，产前可卡因暴露状态或可卡因暴露水平与儿童行为（CBCL外部化和内部化评分或8个CBCL子量表评分）之间无关联。结论：基于目前主要照顾者的标准化评级，该证据未能支持假设的宫内可卡因暴露学龄儿童可卡因相关行为问题。这一研究路线的下一步是从其他被调查者那里获得标准化的评级（例如，教师、青年自我报告）。
Aim - This study examines the relationship between prenatal cocaine exposure and parent-reported child behavior problems at age 7 years. Methods - Data are from 407 African-American children (210 cocaine-exposed, 197 non-cocaine-exposed) enrolled prospectively at birth in a longitudinal study on the neurodevelopmental consequences of in utero exposure to cocaine. Prenatal cocaine exposure was assessed at delivery through maternal self-report and bioassays (maternal and infant urine and infant meconium). The Achenbach Child Behavior Checklist (CBCL), a measure of childhood externalizing and internalizing behavior problems, was completed by the child's current primary caregiver during an assessment visit scheduled when the child was seven years old. Results - Structural equation and GLM/GEE models disclosed no association linking prenatal cocaine exposure status or level of cocaine exposure to child behavior (CBCL Externalizing and Internalizing scores or the eight CBCL subscale scores). Conclusions - This evidence, based on standardized ratings by the current primary caregiver, fails to support hypothesized cocaine-associated behavioral problems in school-aged children with in utero cocaine exposure. A next step in this line of research is to secure standardized ratings from other informants (e.g., teachers, youth self-report).