Osmotic scan ektacytometry in clinical diagnosis
Osmotic scan ektacytometry in clinical diagnosis
复制标题
DOI：
10.1097/00043426-199605000-00005
复制
发表时间：
1996-05-01
影响因子：
1.2
通讯作者：
Ravindranath, Y
中科院分区：
文献类型：
--
作者：
Johnson, RM;Ravindranath, Y
目的：红细胞变形性测量在溶血性贫血诊断中的应用进行了回顾。患者和方法：对500例患者的结果进行了讨论。红细胞的特点是通过自动测量的细胞变形性的张力的介质是不同的（渗透扫描ektacytometry）。结果：测量产生一个可靠的鉴定溶血性贫血引起的缺陷或异常的红细胞结构蛋白。此外，它可以以良好的可靠性发出糖酵解酶缺乏症的信号。扫描在15分钟内完成，因此可以快速指示溶血性贫血的类型。结论：红细胞变形性分析可为溶血性贫血的诊断提供一种有价值的补充方法。
Purpose: The use of red blood cell deformability measurements in the diagnosis of hemolytic anemia is reviewed.Patients and Methods: Results from 500 individuals are discussed. Erythrocytes were characterized by the automated measurement of cell deformability as the tonicity of the medium is varied (osmotic scan ektacytometry).Results: The measurement yields a reliable identification of hemolytic anemias caused by deficiencies or abnormalities in erythrocyte structural proteins. In addition, it can, with good reliability, signal the presence of a glycolytic enzyme deficiency. The scan is complete in 15 min, and can therefore give a rapid indication of the type of hemolytic anemia. The osmotic scans of other hemolytic anemias are also discussed.Conclusion: The analysis of red blood cell deformability can offer a valuable addition to diagnostic methods in hemolytic anemia.