T2 relaxation time histograms in multiple sclerosis
T2 relaxation time histograms in multiple sclerosis
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DOI：
10.1016/s0730-725x(02)00623-9
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发表时间：
2002-12-01
影响因子：
2.5
通讯作者：
Majumdar, S
中科院分区：
文献类型：
--
作者：
Grenier, D;Pelletier, D;Majumdar, S
利用多回波磁共振成像序列，可以在体内精确测量脑实质的横向弛豫时间T-2和T-2直方图。在T-2测量误差的估计是使用硫酸铜掺杂水的幻影。在体内T-2评估之前，计算校正因子并将其应用于每个体素的信号强度。这些修正后的T-2与硫酸铜浓度计算的理论值很好地吻合。然后将该技术应用于计算大脑的T-2直方图。研究人群由正常志愿者和多发性硬化症患者组成。校正后的T-2直方图方法区分了正常对照人群和MS人群，也区分了复发缓解患者和原发性进展或继发性进展患者。此外，使用这种方法，我们能够在MS患者中检测到白质的T-2向更高值的整体转移。本研究结果表明，该方法易于实现，可用于MS病理表征。(C) 2002爱思唯尔科学有限公司版权所有。
An accurate measurement of the transverse relaxation time T-2, and the histogram of T-2, in the brain parenchyma can be accomplished in vivo using a multi-echo magnetic resonance imaging sequence. An estimate of the error in the T-2 measurement is derived using copper sulfate doped water phantoms. Correction factors are calculated and applied to the signal intensity of each voxel prior to the in vivo T-2 evaluation. These corrected T-2 are in good agreement with the theoretical values calculated from copper sulfate concentrations. This technique is then applied to calculate T-2 histograms of the brain. The population studied was composed of normal volunteers and multiple sclerosis patients. The corrected T-2 histogram method discriminates the normal control population from the MS population, and also discriminates between relapsing-remitting patients and primary progressive or secondary progressive patients. Moreover using this approach we are able to detect in MS patients a global shift of the T-2 of the white mater toward higher values. The results of this study showed that the method is easy to implement and may be used to characterize MS pathology. (C) 2002 Elsevier Science Inc. All rights reserved.