Sodium‐coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development
Sodium‐coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development
复制标题
DOI：
10.1111/hepr.12069
复制
发表时间：
2013-11
影响因子：
4.2
通讯作者：
H. Kondou;M. Kawai;Kanako Tachikawa;A. Kimoto;M. Yamagata;Tomoko Koinuma;M. Yamazaki;M. Nakayama;S. Mushiake;K. Ozono;T. Michigami
中科院分区：
文献类型：
--
作者：
H. Kondou;M. Kawai;Kanako Tachikawa;A. Kimoto;M. Yamagata;Tomoko Koinuma;M. Yamazaki;M. Nakayama;S. Mushiake;K. Ozono;T. Michigami
肝细胞核因子（hepatocyte nuclear factor，HNF）4α调控胎肝发育的分子机制尚未完全阐明。我们在肝脏发育过程中筛选了HNF 4 α的下游分子，并鉴定了钠偶联中性氨基酸转运蛋白（SNAT）4。本研究旨在探讨HNF4α对SNAT 4的调控作用及其在肝细胞分化中的作用。
The molecular mechanisms by which hepatocyte nuclear factor (HNF)4α regulates fetal liver development have not been fully elucidated. We screened the downstream molecules of HNF4α during liver development and identified sodium‐coupled neutral amino acid transporter (SNAT)4. The aim of this study is to investigate the regulation of SNAT4 by HNF4α and to clarify its roles in differentiating hepatocytes.